261919

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 300190..300712 Replicon plasmid pKP18-231-1
Accession NZ_CP109608
Organism Klebsiella pneumoniae strain KP18-231

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag OGW23_RS27710 Protein ID WP_004181778.1
Coordinates 300428..300712 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag OGW23_RS27705 Protein ID WP_004181777.1
Coordinates 300190..300438 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OGW23_RS27685 (OGW23_27690) 295360..296217 - 858 WP_064371183.1 hypothetical protein -
OGW23_RS27690 (OGW23_27695) 296277..296630 - 354 WP_042927270.1 hypothetical protein -
OGW23_RS27695 (OGW23_27700) 296766..297770 - 1005 WP_064371184.1 hypothetical protein -
OGW23_RS27700 (OGW23_27705) 298099..299898 - 1800 WP_064371185.1 ATP-dependent helicase -
OGW23_RS27705 (OGW23_27710) 300190..300438 + 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OGW23_RS27710 (OGW23_27715) 300428..300712 + 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OGW23_RS27715 (OGW23_27720) 300733..301104 - 372 WP_223884736.1 type II toxin-antitoxin system PrlF family antitoxin -
OGW23_RS27720 (OGW23_27725) 301219..301401 + 183 WP_044349315.1 type II toxin-antitoxin system HicA family toxin -
OGW23_RS27725 (OGW23_27730) 301445..301876 + 432 WP_044349313.1 hypothetical protein -
OGW23_RS27730 (OGW23_27735) 301881..302168 + 288 WP_044349311.1 helix-turn-helix transcriptional regulator -
OGW23_RS27735 (OGW23_27740) 302967..303245 + 279 WP_044349308.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B / aac(3)-IId / mph(A) / sul1 / qacE / qnrB6 / aadA16 / dfrA27 / ARR-3 katA 1..368951 368951


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T261919 WP_004181778.1 NZ_CP109608:300428-300712 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT261919 WP_004181777.1 NZ_CP109608:300190-300438 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References