261918

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 87506..88263 Replicon plasmid pKP18-231-1
Accession NZ_CP109608
Organism Klebsiella pneumoniae strain KP18-231

Toxin (Protein)


Gene name tacT Uniprot ID A0A2J4ZXV7
Locus tag OGW23_RS26625 Protein ID WP_029497408.1
Coordinates 87781..88263 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag OGW23_RS26620 Protein ID WP_094645258.1
Coordinates 87506..87793 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OGW23_RS26605 (OGW23_26610) 83679..85048 + 1370 WP_094645257.1 IS3 family transposase -
OGW23_RS26610 (OGW23_26615) 85574..86146 + 573 WP_094645259.1 cytochrome b/b6 domain-containing protein -
OGW23_RS26615 (OGW23_26620) 86346..87269 + 924 WP_000167917.1 cation diffusion facilitator family transporter -
OGW23_RS26620 (OGW23_26625) 87506..87793 + 288 WP_094645258.1 DUF1778 domain-containing protein Antitoxin
OGW23_RS26625 (OGW23_26630) 87781..88263 + 483 WP_029497408.1 GNAT family N-acetyltransferase Toxin
OGW23_RS26630 (OGW23_26635) 88544..88696 + 153 Protein_98 DUF5431 family protein -
OGW23_RS26635 (OGW23_26640) 88644..88763 + 120 WP_223884740.1 Hok/Gef family protein -
OGW23_RS26640 (OGW23_26645) 88971..89231 - 261 WP_009653224.1 hypothetical protein -
OGW23_RS26645 (OGW23_26650) 89771..90742 + 972 WP_009653249.1 hypothetical protein -
OGW23_RS26650 (OGW23_26655) 91105..91482 - 378 WP_042927811.1 hypothetical protein -
OGW23_RS26655 (OGW23_26660) 93017..93232 + 216 WP_009653220.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B / aac(3)-IId / mph(A) / sul1 / qacE / qnrB6 / aadA16 / dfrA27 / ARR-3 katA 1..368951 368951
- flank IS/Tn - - 84245..85048 803


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17599.34 Da        Isoelectric Point: 9.8719

>T261918 WP_029497408.1 NZ_CP109608:87781-88263 [Klebsiella pneumoniae]
VGRLTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQQRTLFLRLP

Download         Length: 483 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10955.66 Da        Isoelectric Point: 4.5141

>AT261918 WP_094645258.1 NZ_CP109608:87506-87793 [Klebsiella pneumoniae]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVVDD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4ZXV7

Antitoxin

Source ID Structure

References