Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 4925559..4927240 | Replicon | chromosome |
| Accession | NZ_CP109607 | ||
| Organism | Klebsiella pneumoniae strain KP18-231 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | - |
| Locus tag | OGW23_RS24270 | Protein ID | WP_193525093.1 |
| Coordinates | 4925559..4926476 (-) | Length | 306 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | W8UPQ8 |
| Locus tag | OGW23_RS24275 | Protein ID | WP_004151732.1 |
| Coordinates | 4926482..4927240 (-) | Length | 253 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OGW23_RS24250 (OGW23_24255) | 4920865..4922385 | + | 1521 | WP_002885173.1 | sugar ABC transporter ATP-binding protein | - |
| OGW23_RS24255 (OGW23_24260) | 4922382..4923380 | + | 999 | WP_002885172.1 | ribose ABC transporter permease | - |
| OGW23_RS24260 (OGW23_24265) | 4923411..4924352 | + | 942 | WP_002885156.1 | ABC transporter substrate-binding protein | - |
| OGW23_RS24265 (OGW23_24270) | 4924427..4925434 | + | 1008 | WP_004151731.1 | carbohydrate kinase family protein | - |
| OGW23_RS24270 (OGW23_24275) | 4925559..4926476 | - | 918 | WP_193525093.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| OGW23_RS24275 (OGW23_24280) | 4926482..4927240 | - | 759 | WP_004151732.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| OGW23_RS24280 (OGW23_24285) | 4927326..4928054 | - | 729 | WP_002885152.1 | response regulator transcription factor | - |
| OGW23_RS24285 (OGW23_24290) | 4928327..4930474 | + | 2148 | WP_077598858.1 | formate dehydrogenase subunit alpha | - |
| OGW23_RS24290 (OGW23_24295) | 4930704..4931390 | + | 687 | WP_004151733.1 | tetratricopeptide repeat protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34657.17 Da Isoelectric Point: 5.7772
>T261916 WP_193525093.1 NZ_CP109607:c4926476-4925559 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIVVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIVVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
Antitoxin
Download Length: 253 a.a. Molecular weight: 28564.92 Da Isoelectric Point: 10.0870
>AT261916 WP_004151732.1 NZ_CP109607:c4927240-4926482 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|