Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4769375..4769891 Replicon chromosome
Accession NZ_CP109607
Organism Klebsiella pneumoniae strain KP18-231

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag OGW23_RS23470 Protein ID WP_002886902.1
Coordinates 4769375..4769659 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OGW23_RS23475 Protein ID WP_002886901.1
Coordinates 4769649..4769891 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OGW23_RS23445 (OGW23_23450) 4764859..4765122 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
OGW23_RS23450 (OGW23_23455) 4765252..4765425 + 174 WP_002886906.1 hypothetical protein -
OGW23_RS23455 (OGW23_23460) 4765428..4766171 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OGW23_RS23460 (OGW23_23465) 4766528..4768666 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
OGW23_RS23465 (OGW23_23470) 4768907..4769371 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OGW23_RS23470 (OGW23_23475) 4769375..4769659 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OGW23_RS23475 (OGW23_23480) 4769649..4769891 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OGW23_RS23480 (OGW23_23485) 4769969..4771879 - 1911 WP_004152270.1 PRD domain-containing protein -
OGW23_RS23485 (OGW23_23490) 4771902..4773056 - 1155 WP_002886900.1 lactonase family protein -
OGW23_RS23490 (OGW23_23495) 4773122..4773862 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T261915 WP_002886902.1 NZ_CP109607:c4769659-4769375 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT261915 WP_002886901.1 NZ_CP109607:c4769891-4769649 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References