Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2708251..2709839 Replicon chromosome
Accession NZ_CP109607
Organism Klebsiella pneumoniae strain KP18-231

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag OGW23_RS13410 Protein ID WP_004199851.1
Coordinates 2708251..2709573 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag OGW23_RS13415 Protein ID WP_002904790.1
Coordinates 2709573..2709839 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OGW23_RS13395 (OGW23_13400) 2703316..2705817 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
OGW23_RS13400 (OGW23_13405) 2705805..2706809 + 1005 WP_004199852.1 fimbrial protein -
OGW23_RS13405 (OGW23_13410) 2706942..2708234 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
OGW23_RS13410 (OGW23_13415) 2708251..2709573 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
OGW23_RS13415 (OGW23_13420) 2709573..2709839 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OGW23_RS13420 (OGW23_13425) 2710105..2710431 - 327 WP_002904788.1 hydroxyisourate hydrolase -
OGW23_RS13425 (OGW23_13430) 2710428..2710928 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
OGW23_RS13430 (OGW23_13435) 2710906..2712285 - 1380 Protein_2631 nucleobase:cation symporter-2 family protein -
OGW23_RS13435 (OGW23_13440) 2712631..2713785 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
OGW23_RS13440 (OGW23_13445) 2713766..2714689 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T261912 WP_004199851.1 NZ_CP109607:c2709573-2708251 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT261912 WP_002904790.1 NZ_CP109607:c2709839-2709573 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References