261903

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4579028..4579616 Replicon chromosome
Accession NZ_CP109606
Organism Pseudomonas putida strain QH1

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag OGV21_RS20750 Protein ID WP_264316450.1
Coordinates 4579028..4579330 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID B0KS04
Locus tag OGV21_RS20755 Protein ID WP_012273611.1
Coordinates 4579323..4579616 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OGV21_RS20725 4575042..4575170 - 129 WP_009683677.1 PA1414 family protein -
OGV21_RS20730 4575295..4576188 - 894 WP_012273606.1 LysR family transcriptional regulator -
OGV21_RS20735 4576295..4577455 + 1161 WP_060515451.1 MFS transporter -
OGV21_RS20740 4577424..4578350 - 927 WP_012273608.1 DMT family transporter -
OGV21_RS20745 4578456..4578851 - 396 WP_012273609.1 hypothetical protein -
OGV21_RS20750 4579028..4579330 + 303 WP_264316450.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OGV21_RS20755 4579323..4579616 + 294 WP_012273611.1 putative addiction module antidote protein Antitoxin
OGV21_RS20760 4579706..4579978 + 273 WP_012273612.1 hypothetical protein -
OGV21_RS20765 4580101..4581462 - 1362 WP_069943273.1 DEAD/DEAH box helicase -
OGV21_RS20770 4581566..4582867 + 1302 WP_012273614.1 mechanosensitive ion channel family protein -
OGV21_RS20775 4582884..4583297 - 414 WP_264316451.1 alternative ribosome rescue aminoacyl-tRNA hydrolase ArfB -
OGV21_RS20780 4583363..4584298 - 936 WP_264316452.1 AEC family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4571231..4590628 19397


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(6-94)

Antitoxin

Cro/C1-type helix-turn-helix domain

(45-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11410.01 Da        Isoelectric Point: 10.8773

>T261903 WP_264316450.1 NZ_CP109606:4579028-4579330 [Pseudomonas putida]
MKKIESSSFRHWVTGLRDSSARARIISRINRLMEGLPGDVSPVGHGVSELRIHYGPGYRVYFHQTGNTFVILLCSGDKSS
QQRDIKAAHQILRSWRMQND

Download         Length: 303 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10474.89 Da        Isoelectric Point: 4.7906

>AT261903 WP_012273611.1 NZ_CP109606:4579323-4579616 [Pseudomonas putida]
MTETFSEFDPAEYLTTPEAIAQFMTDALETGDAGYVAKAVGVVARAKGMSELAKETGLSREQLYRSFSEHGNPTLKSFLT
VMKALGIDMTARPHLAG

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7Y3XSY8

References