Detailed information of TA system TA026190

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-PHD
• Location: 3259891..3260576
• Replicon: chromosome
• Accession: NC_017039
• Organism: Synechocystis sp. PCC 6803 substr. PCC-P

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A6P1VMJ8
• Locus tag: SYNPCCP_RS15135
• Protein ID: WP_010874101.1
• Coordinates: 3259891..3260286 (-)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: SYNPCCP_RS15140
• Protein ID: WP_010874102.1
• Coordinates: 3260298..3260576 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SYNPCCP_RS15120	3255520..3257715	-	2196	WP_010874098.1	phosphoketolase	-
SYNPCCP_RS15125	3257964..3259103	-	1140	WP_010874099.1	site-2 protease family protein	-
SYNPCCP_RS15130	3259233..3259889	+	657	WP_010874100.1	YggS family pyridoxal phosphate-dependent enzyme	-
SYNPCCP_RS15135	3259891..3260286	-	396	WP_010874101.1	type II toxin-antitoxin system VapC family toxin	Toxin
SYNPCCP_RS15140	3260298..3260576	-	279	WP_010874102.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SYNPCCP_RS15145	3260646..3261989	-	1344	WP_010874103.1	FIST C-terminal domain-containing protein	-
SYNPCCP_RS15150	3262117..3264849	+	2733	WP_010874104.1	valine--tRNA ligase	-
SYNPCCP_RS15155	3265071..3265376	-	306	WP_197525966.1	NADH-quinone oxidoreductase subunit NuoK	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 15081.50 Da
• Isoelectric Point: 4.5594

>T26190 WP_010874101.1 NC_017039:c3260286-3259891 [Synechocystis sp. PCC 6803 substr. PCC-P]
VKLLLDTQCWLWWFTEPEKLNEDAISQIIDETNEIWLSVASIWEMSIKTSIGKLPLPENIDDYILSRMVKLGAEFLDIKT
RHALQVATLPLHHRDPFDRIIIAQAQTENMLLISADSMFKNYGVSLLWAGV

Nucleotide

• Length: 396 bp

>T26190 NC_017039:c3260286-3259891 [Synechocystis sp. PCC 6803 substr. PCC-P]
GTGAAACTTTTGTTGGATACCCAGTGCTGGTTATGGTGGTTTACTGAGCCGGAAAAATTGAACGAAGATGCAATTTCCCA
GATCATAGATGAGACAAACGAAATATGGCTTTCTGTTGCCAGTATTTGGGAAATGTCAATTAAGACTTCCATCGGTAAAC
TGCCCTTGCCAGAAAATATTGACGACTACATTCTCAGTCGCATGGTGAAATTGGGTGCTGAGTTCCTGGACATTAAAACC
CGCCATGCCCTGCAAGTTGCGACATTGCCCCTACATCACCGTGATCCGTTTGACAGAATTATCATTGCCCAGGCACAAAC
AGAAAATATGCTGCTAATTAGTGCAGATTCAATGTTTAAAAATTATGGAGTCTCTTTGTTATGGGCGGGAGTATAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10084.59 Da
• Isoelectric Point: 4.0201

>AT26190 WP_010874102.1 NC_017039:c3260576-3260298 [Synechocystis sp. PCC 6803 substr. PCC-P]
MIGVSVNPEKLGSTMETVNVDQIEINLPELLYSIKPGEEVIVADQGIPIAKLVPLQRQKSVDRCSSLGVDRGLFVVPDDF
NDPLPNDIWPLS

Nucleotide

• Length: 279 bp

>AT26190 NC_017039:c3260576-3260298 [Synechocystis sp. PCC 6803 substr. PCC-P]
ATGATCGGAGTTAGCGTTAATCCAGAGAAACTAGGATCCACTATGGAGACCGTCAATGTTGACCAAATAGAAATCAATCT
TCCTGAGCTTTTGTACAGTATCAAACCAGGGGAAGAAGTCATCGTTGCTGACCAGGGTATTCCCATTGCTAAGTTGGTTC
CTCTGCAAAGGCAAAAATCCGTGGATCGATGCTCCAGCTTAGGGGTAGATCGAGGATTATTTGTAGTGCCAGATGACTTT
AACGATCCTTTACCAAATGATATTTGGCCATTATCTTGA

Structures

Toxin

• AlphaFold DB: A0A6P1VMJ8