Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4655238..4655754 Replicon chromosome
Accession NZ_CP109604
Organism Klebsiella pneumoniae strain KP2022

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag KP2022_RS22665 Protein ID WP_009309309.1
Coordinates 4655238..4655522 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KP2022_RS22670 Protein ID WP_002886901.1
Coordinates 4655512..4655754 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KP2022_RS22640 (4650722) 4650722..4650985 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
KP2022_RS22645 (4651115) 4651115..4651288 + 174 WP_002886906.1 hypothetical protein -
KP2022_RS22650 (4651291) 4651291..4652034 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KP2022_RS22655 (4652391) 4652391..4654529 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
KP2022_RS22660 (4654770) 4654770..4655234 + 465 WP_047718307.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KP2022_RS22665 (4655238) 4655238..4655522 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KP2022_RS22670 (4655512) 4655512..4655754 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KP2022_RS22675 (4655832) 4655832..4657742 - 1911 WP_004152270.1 PRD domain-containing protein -
KP2022_RS22680 (4657765) 4657765..4658919 - 1155 WP_047718309.1 lactonase family protein -
KP2022_RS22685 (4658986) 4658986..4659726 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T261896 WP_009309309.1 NZ_CP109604:c4655522-4655238 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT261896 WP_002886901.1 NZ_CP109604:c4655754-4655512 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References