Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4575193..4575884 Replicon chromosome
Accession NZ_CP109604
Organism Klebsiella pneumoniae strain KP2022

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag KP2022_RS22335 Protein ID WP_129073948.1
Coordinates 4575193..4575534 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A2A5MHA6
Locus tag KP2022_RS22340 Protein ID WP_019725272.1
Coordinates 4575558..4575884 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KP2022_RS22300 (4570416) 4570416..4570751 - 336 WP_223366797.1 hypothetical protein -
KP2022_RS22305 (4570715) 4570715..4571359 - 645 WP_164972967.1 hypothetical protein -
KP2022_RS22310 (4571356) 4571356..4572048 - 693 WP_040173594.1 HNH endonuclease signature motif containing protein -
KP2022_RS22315 (4572245) 4572245..4572827 + 583 Protein_4375 tyrosine-type recombinase/integrase -
KP2022_RS22320 (4572983) 4572983..4573876 + 894 WP_040173596.1 hypothetical protein -
KP2022_RS22325 (4573955) 4573955..4574239 + 285 Protein_4377 helix-turn-helix domain-containing protein -
KP2022_RS22330 (4574245) 4574245..4575078 - 834 WP_040173641.1 DUF4942 domain-containing protein -
KP2022_RS22335 (4575193) 4575193..4575534 - 342 WP_129073948.1 TA system toxin CbtA family protein Toxin
KP2022_RS22340 (4575558) 4575558..4575884 - 327 WP_019725272.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KP2022_RS22345 (4575898) 4575898..4576374 - 477 WP_019725273.1 DNA repair protein RadC -
KP2022_RS22350 (4576384) 4576384..4576830 - 447 WP_040173599.1 antirestriction protein -
KP2022_RS22355 (4577041) 4577041..4577730 - 690 WP_009309812.1 hypothetical protein -
KP2022_RS22360 (4578295) 4578295..4579185 - 891 WP_085163516.1 YfjP family GTPase -
KP2022_RS22365 (4579268) 4579268..4580356 - 1089 WP_085163515.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4557653..4597048 39395


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(8-107)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12885.93 Da        Isoelectric Point: 8.5195

>T261895 WP_129073948.1 NZ_CP109604:c4575534-4575193 [Klebsiella pneumoniae]
MKTLPATIQRAAKPCPSPVTVWQMLLTRLLEQHYGLTMNDTPFSDETVIQEHINAGITLVDAVNFLVEKYELVRIDRRGF
NCQEQSPYLGAVDILRARQATGLLRQRHLPSIR

Download         Length: 342 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12276.01 Da        Isoelectric Point: 6.9560

>AT261895 WP_019725272.1 NZ_CP109604:c4575884-4575558 [Klebsiella pneumoniae]
MPLTDAIQWGLKRSFTPNFGARLVQEGNRLHYLADRANITGKFGDAECLKLEEAFPHFIRQMELMLSTGELNPRHAHSVT
LYHNAFTCEADTLGSCGYVYIVIYPTQR

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2A5MHA6

References