Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 780992..781649 Replicon chromosome
Accession NZ_CP109604
Organism Klebsiella pneumoniae strain KP2022

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KP2022_RS03870 Protein ID WP_002916310.1
Coordinates 781239..781649 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KP2022_RS03865 Protein ID WP_002916312.1
Coordinates 780992..781258 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KP2022_RS03840 (776148) 776148..777581 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
KP2022_RS03845 (777700) 777700..778428 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KP2022_RS03850 (778478) 778478..778789 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
KP2022_RS03855 (778953) 778953..779612 + 660 WP_002916317.1 hemolysin III family protein -
KP2022_RS03860 (779763) 779763..780746 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
KP2022_RS03865 (780992) 780992..781258 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KP2022_RS03870 (781239) 781239..781649 + 411 WP_002916310.1 protein YgfX Toxin
KP2022_RS03875 (781656) 781656..782177 - 522 WP_002916308.1 flavodoxin FldB -
KP2022_RS03880 (782278) 782278..783174 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KP2022_RS03885 (783197) 783197..783910 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KP2022_RS03890 (783916) 783916..785649 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T261886 WP_002916310.1 NZ_CP109604:781239-781649 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT261886 WP_002916312.1 NZ_CP109604:780992-781258 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References