Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 22419..23050 Replicon chromosome
Accession NZ_CP109603
Organism Pseudomonas putida strain SEH01

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag OGV19_RS00090 Protein ID WP_264311566.1
Coordinates 22419..22643 (+) Length 75 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OGV19_RS00095 Protein ID WP_264311567.1
Coordinates 22643..23050 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OGV19_RS00065 17550..18041 + 492 WP_264311562.1 OmpA family protein -
OGV19_RS00070 18174..19124 - 951 WP_264311563.1 LysR family transcriptional regulator -
OGV19_RS00075 19257..20783 + 1527 WP_264311564.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
OGV19_RS00080 20794..21681 + 888 WP_264311565.1 3-hydroxyisobutyrate dehydrogenase -
OGV19_RS00085 21791..22135 - 345 WP_003251579.1 cupin domain-containing protein -
OGV19_RS00090 22419..22643 + 225 WP_264311566.1 type II toxin-antitoxin system HicA family toxin Toxin
OGV19_RS00095 22643..23050 + 408 WP_264311567.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OGV19_RS00100 23083..24015 - 933 WP_027595453.1 phosphatidate cytidylyltransferase -
OGV19_RS00105 24017..24640 - 624 WP_264311568.1 lysophospholipid acyltransferase family protein -
OGV19_RS00110 24651..25082 - 432 WP_264311569.1 hypothetical protein -
OGV19_RS00115 25079..26401 - 1323 WP_264311570.1 phosphatase PAP2/dual specificity phosphatase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8243.39 Da        Isoelectric Point: 10.8123

>T261875 WP_264311566.1 NZ_CP109603:22419-22643 [Pseudomonas putida]
VRSREVIQIIEADGWYEVEVKGSHHQFRHPVKRGRVTVPHPKSDLPKGTVHNILKQAGLKQPSSPSSSIIRGDA

Download         Length: 225 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14697.50 Da        Isoelectric Point: 4.8984

>AT261875 WP_264311567.1 NZ_CP109603:22643-23050 [Pseudomonas putida]
MKFPVVLHKDADSDYGVTVPDVPGCFSAGASVSQALENIQEALALHFEGLVADNEALPQAQEIDVHVANPDYHGGVWAVV
DFDVTPYLGKAVRFNATLPENLLQRIDEKVKRDHRYASRSGFLASAALRELASVH

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References