Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 54627..55252 Replicon plasmid p1
Accession NZ_CP109602
Organism Escherichia coli strain TL-14

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag OGV15_RS23490 Protein ID WP_000911313.1
Coordinates 54854..55252 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag OGV15_RS23485 Protein ID WP_000450520.1
Coordinates 54627..54854 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OGV15_RS23485 (54627) 54627..54854 + 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin
OGV15_RS23490 (54854) 54854..55252 + 399 WP_000911313.1 type II toxin-antitoxin system VapC family toxin Toxin
OGV15_RS23495 (55261) 55261..57414 - 2154 WP_000009324.1 type IV conjugative transfer system coupling protein TraD -
OGV15_RS23500 (57667) 57667..58398 - 732 WP_023565183.1 conjugal transfer complement resistance protein TraT -
OGV15_RS23505 (58430) 58430..58927 - 498 WP_000605859.1 entry exclusion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaTEM-1B / tet(B) / aph(3'')-Ib / aph(6)-Id espP / faeJ / faeI / faeH / faeF / faeE / faeD / faeC 1..145661 145661


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14901.15 Da        Isoelectric Point: 7.8605

>T261871 WP_000911313.1 NZ_CP109602:54854-55252 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT261871 WP_000450520.1 NZ_CP109602:54627-54854 [Escherichia coli]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References