Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4260352..4260849 Replicon chromosome
Accession NZ_CP109601
Organism Escherichia coli strain TL-14

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag OGV15_RS20805 Protein ID WP_001173343.1
Coordinates 4260352..4260525 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag OGV15_RS20810 Protein ID WP_000398619.1
Coordinates 4260553..4260849 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OGV15_RS20795 (4257022) 4257022..4258479 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
OGV15_RS20800 (4258716) 4258716..4260233 + 1518 WP_001295074.1 lysine--tRNA ligase -
OGV15_RS20805 (4260352) 4260352..4260525 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
OGV15_RS20810 (4260553) 4260553..4260849 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
OGV15_RS20815 (4261076) 4261076..4261348 - 273 WP_000405651.1 GNAT family N-acetyltransferase -
OGV15_RS20820 (4261360) 4261360..4261590 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
OGV15_RS20825 (4261771) 4261771..4263402 + 1632 WP_001216477.1 sensor histidine kinase -
OGV15_RS20830 (4263399) 4263399..4264118 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T261865 WP_001173343.1 NZ_CP109601:c4260525-4260352 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT261865 WP_000398619.1 NZ_CP109601:c4260849-4260553 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References