Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1026035..1026618 Replicon chromosome
Accession NZ_CP109601
Organism Escherichia coli strain TL-14

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag OGV15_RS04980 Protein ID WP_049253269.1
Coordinates 1026283..1026618 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1V2T5M9
Locus tag OGV15_RS04975 Protein ID WP_000581941.1
Coordinates 1026035..1026283 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OGV15_RS04965 (1022374) 1022374..1023675 + 1302 WP_023281448.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -
OGV15_RS04970 (1023723) 1023723..1025957 + 2235 WP_000226815.1 GTP pyrophosphokinase -
OGV15_RS04975 (1026035) 1026035..1026283 + 249 WP_000581941.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
OGV15_RS04980 (1026283) 1026283..1026618 + 336 WP_049253269.1 endoribonuclease MazF Toxin
OGV15_RS04985 (1026689) 1026689..1027480 + 792 WP_001071648.1 nucleoside triphosphate pyrophosphohydrolase -
OGV15_RS04990 (1027708) 1027708..1029346 + 1639 Protein_977 CTP synthase (glutamine hydrolyzing) -
OGV15_RS04995 (1029434) 1029434..1030732 + 1299 WP_000036723.1 phosphopyruvate hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12197.18 Da        Isoelectric Point: 8.7218

>T261851 WP_049253269.1 NZ_CP109601:1026283-1026618 [Escherichia coli]
MVSRYVPDMGDLIWVDFDPTKGSEQARHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG

Download         Length: 336 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9385.76 Da        Isoelectric Point: 4.4665

>AT261851 WP_000581941.1 NZ_CP109601:1026035-1026283 [Escherichia coli]
MIHSSVKRWGNSPAVRIPTTLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1V2T5M9

References