Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 46608..47443 Replicon chromosome
Accession NZ_CP109601
Organism Escherichia coli strain TL-14

Toxin (Protein)


Gene name yeeV Uniprot ID A0A8E0IXC7
Locus tag OGV15_RS00245 Protein ID WP_000854824.1
Coordinates 46608..46985 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7MK11
Locus tag OGV15_RS00250 Protein ID WP_001285610.1
Coordinates 47075..47443 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OGV15_RS00215 (42226) 42226..43410 - 1185 WP_001172876.1 sugar efflux transporter -
OGV15_RS00220 (43807) 43807..43968 - 162 Protein_43 virulence RhuM family protein -
OGV15_RS00225 (44241) 44241..44938 + 698 WP_151884388.1 IS1 family transposase -
OGV15_RS00230 (44982) 44982..45824 - 843 WP_001290169.1 DUF4942 domain-containing protein -
OGV15_RS00235 (45909) 45909..46106 - 198 WP_000839265.1 DUF957 domain-containing protein -
OGV15_RS00240 (46123) 46123..46611 - 489 WP_000761682.1 DUF5983 family protein -
OGV15_RS00245 (46608) 46608..46985 - 378 WP_000854824.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
OGV15_RS00250 (47075) 47075..47443 - 369 WP_001285610.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
OGV15_RS00255 (47523) 47523..47744 - 222 WP_000692350.1 DUF987 domain-containing protein -
OGV15_RS00260 (47831) 47831..48307 - 477 WP_124047491.1 RadC family protein -
OGV15_RS00265 (48322) 48322..48801 - 480 WP_000706975.1 antirestriction protein -
OGV15_RS00270 (49067) 49067..49885 - 819 WP_001175165.1 DUF932 domain-containing protein -
OGV15_RS00275 (49975) 49975..50208 - 234 WP_001278293.1 DUF905 family protein -
OGV15_RS00280 (50214) 50214..50891 - 678 WP_001097302.1 hypothetical protein -
OGV15_RS00285 (51039) 51039..51719 - 681 WP_001282921.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13930.95 Da        Isoelectric Point: 8.5163

>T261846 WP_000854824.1 NZ_CP109601:c46985-46608 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIETGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13606.39 Da        Isoelectric Point: 6.0618

>AT261846 WP_001285610.1 NZ_CP109601:c47443-47075 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References