261834

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3632224..3632842 Replicon chromosome
Accession NZ_CP107720
Organism Escherichia coli strain 2021CK-01361

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N4T39_RS17700 Protein ID WP_001291435.1
Coordinates 3632624..3632842 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N4T39_RS17695 Protein ID WP_000344800.1
Coordinates 3632224..3632598 (+) Length 125 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4T39_RS17685 (3627313) 3627313..3628506 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N4T39_RS17690 (3628529) 3628529..3631678 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
N4T39_RS17695 (3632224) 3632224..3632598 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N4T39_RS17700 (3632624) 3632624..3632842 + 219 WP_001291435.1 HHA domain-containing protein Toxin
N4T39_RS17705 (3633014) 3633014..3633565 + 552 WP_000102564.1 maltose O-acetyltransferase -
N4T39_RS17710 (3633681) 3633681..3634151 + 471 WP_000136192.1 YlaC family protein -
N4T39_RS17715 (3634315) 3634315..3635865 + 1551 WP_001514985.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N4T39_RS17720 (3635907) 3635907..3636260 - 354 WP_000878140.1 DUF1428 domain-containing protein -
N4T39_RS17730 (3636639) 3636639..3636950 + 312 WP_000409911.1 MGMT family protein -
N4T39_RS17735 (3636981) 3636981..3637553 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-69)

Antitoxin

(1-117)


Sequences


Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T261834 WP_001291435.1 NZ_CP107720:3632624-3632842 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp


Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT261834 WP_000344800.1 NZ_CP107720:3632224-3632598 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2


Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References