Detailed information of TA system TA026182

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-PHD
• Location: 3259781..3260466
• Replicon: chromosome
• Accession: NC_017038
• Organism: Synechocystis sp. PCC 6803 substr. GT-I

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A6P1VMJ8
• Locus tag: SYNGTI_RS15095
• Protein ID: WP_010874101.1
• Coordinates: 3259781..3260176 (-)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: SYNGTI_RS15100
• Protein ID: WP_010874102.1
• Coordinates: 3260188..3260466 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SYNGTI_RS15080	3255410..3257605	-	2196	WP_010874098.1	phosphoketolase	-
SYNGTI_RS15085	3257854..3258993	-	1140	WP_010874099.1	site-2 protease family protein	-
SYNGTI_RS15090	3259123..3259779	+	657	WP_010874100.1	YggS family pyridoxal phosphate-dependent enzyme	-
SYNGTI_RS15095	3259781..3260176	-	396	WP_010874101.1	type II toxin-antitoxin system VapC family toxin	Toxin
SYNGTI_RS15100	3260188..3260466	-	279	WP_010874102.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SYNGTI_RS15105	3260536..3261879	-	1344	WP_010874103.1	FIST C-terminal domain-containing protein	-
SYNGTI_RS15110	3262007..3264739	+	2733	WP_010874104.1	valine--tRNA ligase	-
SYNGTI_RS15115	3264961..3265266	-	306	WP_197525966.1	NADH-quinone oxidoreductase subunit NuoK	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 15081.50 Da
• Isoelectric Point: 4.5594

>T26182 WP_010874101.1 NC_017038:c3260176-3259781 [Synechocystis sp. PCC 6803 substr. GT-I]
VKLLLDTQCWLWWFTEPEKLNEDAISQIIDETNEIWLSVASIWEMSIKTSIGKLPLPENIDDYILSRMVKLGAEFLDIKT
RHALQVATLPLHHRDPFDRIIIAQAQTENMLLISADSMFKNYGVSLLWAGV

Nucleotide

• Length: 396 bp

>T26182 NC_017038:c3260176-3259781 [Synechocystis sp. PCC 6803 substr. GT-I]
GTGAAACTTTTGTTGGATACCCAGTGCTGGTTATGGTGGTTTACTGAGCCGGAAAAATTGAACGAAGATGCAATTTCCCA
GATCATAGATGAGACAAACGAAATATGGCTTTCTGTTGCCAGTATTTGGGAAATGTCAATTAAGACTTCCATCGGTAAAC
TGCCCTTGCCAGAAAATATTGACGACTACATTCTCAGTCGCATGGTGAAATTGGGTGCTGAGTTCCTGGACATTAAAACC
CGCCATGCCCTGCAAGTTGCGACATTGCCCCTACATCACCGTGATCCGTTTGACAGAATTATCATTGCCCAGGCACAAAC
AGAAAATATGCTGCTAATTAGTGCAGATTCAATGTTTAAAAATTATGGAGTCTCTTTGTTATGGGCGGGAGTATAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10084.59 Da
• Isoelectric Point: 4.0201

>AT26182 WP_010874102.1 NC_017038:c3260466-3260188 [Synechocystis sp. PCC 6803 substr. GT-I]
MIGVSVNPEKLGSTMETVNVDQIEINLPELLYSIKPGEEVIVADQGIPIAKLVPLQRQKSVDRCSSLGVDRGLFVVPDDF
NDPLPNDIWPLS

Nucleotide

• Length: 279 bp

>AT26182 NC_017038:c3260466-3260188 [Synechocystis sp. PCC 6803 substr. GT-I]
ATGATCGGAGTTAGCGTTAATCCAGAGAAACTAGGATCCACTATGGAGACCGTCAATGTTGACCAAATAGAAATCAATCT
TCCTGAGCTTTTGTACAGTATCAAACCAGGGGAAGAAGTCATCGTTGCTGACCAGGGTATTCCCATTGCTAAGTTGGTTC
CTCTGCAAAGGCAAAAATCCGTGGATCGATGCTCCAGCTTAGGGGTAGATCGAGGATTATTTGTAGTGCCAGATGACTTT
AACGATCCTTTACCAAATGATATTTGGCCATTATCTTGA

Structures

Toxin

• AlphaFold DB: A0A6P1VMJ8