261815

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 52122..52802 Replicon chromosome
Accession NZ_CP107720
Organism Escherichia coli strain 2021CK-01361

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag N4T39_RS00260 Protein ID WP_039026306.1
Coordinates 52122..52463 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag N4T39_RS00265 Protein ID WP_039026307.1
Coordinates 52485..52802 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4T39_RS00235 (47602) 47602..47763 - 162 Protein_46 virulence RhuM family protein -
N4T39_RS00245 (49608) 49608..49811 - 204 Protein_48 winged helix-turn-helix domain-containing protein -
N4T39_RS00250 (49810) 49810..50652 - 843 Protein_49 integrase arm-type DNA-binding domain-containing protein -
N4T39_RS00255 (51173) 51173..52006 - 834 WP_039026305.1 DUF4942 domain-containing protein -
N4T39_RS00260 (52122) 52122..52463 - 342 WP_039026306.1 TA system toxin CbtA family protein Toxin
N4T39_RS00265 (52485) 52485..52802 - 318 WP_039026307.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
N4T39_RS00270 (52820) 52820..53041 - 222 WP_000691995.1 DUF987 domain-containing protein -
N4T39_RS00275 (53050) 53050..53526 - 477 WP_039026308.1 RadC family protein -
N4T39_RS00280 (53542) 53542..54000 - 459 WP_039026309.1 antirestriction protein -
N4T39_RS00285 (54115) 54115..54339 - 225 WP_039026310.1 DUF905 domain-containing protein -
N4T39_RS00290 (54435) 54435..55310 - 876 WP_176393125.1 Ivy family c-type lysozyme inhibitor -
N4T39_RS00295 (55421) 55421..55636 - 216 WP_039026311.1 hypothetical protein -
N4T39_RS00300 (55964) 55964..56661 - 698 Protein_59 DeoR family transcriptional regulator -
N4T39_RS00305 (56870) 56870..57694 - 825 WP_039026313.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12825.82 Da        Isoelectric Point: 9.7153

>T261815 WP_039026306.1 NZ_CP107720:c52463-52122 [Escherichia coli]
MKTLPATISRAAKPCLSTVAVWQMLLTRLLEQHYGLTLNDTPFSDVTVIQEHINAGITLADAVNFLVEKYELVRIDRRSF
NCQEQSPYIRAVDILRARQATGLLRQSRNNAVR

Download         Length: 342 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11891.45 Da        Isoelectric Point: 6.9456

>AT261815 WP_039026307.1 NZ_CP107720:c52802-52485 [Escherichia coli]
MSNTTWGLQRDITPRMGARLVQEGNRLHYLADRASITSKFSDAECQKLDIAFPHFISQMESMLTTGEMNPRHAHCVTLYH
NGYTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References