Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/zeta-ParD |
| Location | 3219546..3220551 | Replicon | chromosome |
| Accession | NZ_CP107719 | ||
| Organism | Mycolicibacterium fortuitum strain MF GZ001 | ||
Toxin (Protein)
| Gene name | pezT | Uniprot ID | A0A100WW35 |
| Locus tag | OF855_RS15505 | Protein ID | WP_061265185.1 |
| Coordinates | 3219973..3220551 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | A0A100WWN0 |
| Locus tag | OF855_RS15500 | Protein ID | WP_061265184.1 |
| Coordinates | 3219546..3219935 (+) | Length | 130 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OF855_RS15475 (OF855_15485) | 3215556..3215879 | - | 324 | WP_234790234.1 | GNAT family N-acetyltransferase | - |
| OF855_RS15480 (OF855_15490) | 3215879..3216103 | - | 225 | WP_234790235.1 | hypothetical protein | - |
| OF855_RS15485 (OF855_15495) | 3216135..3216545 | - | 411 | WP_003884798.1 | transglycosylase family protein | - |
| OF855_RS15490 (OF855_15500) | 3216940..3218298 | - | 1359 | WP_061265182.1 | alpha/beta hydrolase-fold protein | - |
| OF855_RS15495 (OF855_15505) | 3218462..3219484 | + | 1023 | WP_061265183.1 | TIGR03617 family F420-dependent LLM class oxidoreductase | - |
| OF855_RS15500 (OF855_15510) | 3219546..3219935 | + | 390 | WP_061265184.1 | hypothetical protein | Antitoxin |
| OF855_RS15505 (OF855_15515) | 3219973..3220551 | + | 579 | WP_061265185.1 | zeta toxin family protein | Toxin |
| OF855_RS15510 (OF855_15520) | 3220623..3221006 | + | 384 | WP_131809118.1 | hypothetical protein | - |
| OF855_RS15515 (OF855_15525) | 3221026..3221661 | - | 636 | WP_061265186.1 | histidine phosphatase family protein | - |
| OF855_RS15520 (OF855_15530) | 3221697..3222053 | - | 357 | WP_003884792.1 | hypothetical protein | - |
| OF855_RS15525 (OF855_15535) | 3222064..3222789 | - | 726 | WP_061265187.1 | thiocyanate hydrolase subunit gamma | - |
| OF855_RS15530 (OF855_15540) | 3222824..3223648 | - | 825 | WP_003884790.1 | nitrile hydratase subunit beta | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21066.16 Da Isoelectric Point: 8.5146
>T261814 WP_061265185.1 NZ_CP107719:3219973-3220551 [Mycolicibacterium fortuitum]
VKRLDLVVGCNGAGKSTFVELTLSPLLPGSPFVNADEIAKHRWPQDPASHSYEAALVAAETRAKLIQLGESFIAETVFSH
PSKLELIDDARAAGYTLILHCLLIPEELAVQRVRHRVRAGGHHVPEKKIRERYQRLWDLVTIAAIRVDSATFYDNSAVSG
PRIVAQIVGGFVVGSPTWPTWTPTALSSRWPG
VKRLDLVVGCNGAGKSTFVELTLSPLLPGSPFVNADEIAKHRWPQDPASHSYEAALVAAETRAKLIQLGESFIAETVFSH
PSKLELIDDARAAGYTLILHCLLIPEELAVQRVRHRVRAGGHHVPEKKIRERYQRLWDLVTIAAIRVDSATFYDNSAVSG
PRIVAQIVGGFVVGSPTWPTWTPTALSSRWPG
Download Length: 579 bp
Antitoxin
Download Length: 130 a.a. Molecular weight: 13625.03 Da Isoelectric Point: 4.4508
>AT261814 WP_061265184.1 NZ_CP107719:3219546-3219935 [Mycolicibacterium fortuitum]
MTETADRVTRFAADLIDSAAAEGARQSRSAKQQLDHWARVGRAVSSRHSAARRKVEAALAGDIALGELTAEEGAVFDAEI
AASIEESLARTDYGKELAARGITTVALDEDGEIVQYLPDGSTAVLAPQQ
MTETADRVTRFAADLIDSAAAEGARQSRSAKQQLDHWARVGRAVSSRHSAARRKVEAALAGDIALGELTAEEGAVFDAEI
AASIEESLARTDYGKELAARGITTVALDEDGEIVQYLPDGSTAVLAPQQ
Download Length: 390 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A100WW35 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A100WWN0 |