261813

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1313438..1314070 Replicon chromosome
Accession NZ_CP107719
Organism Mycolicibacterium fortuitum strain MF GZ001

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag OF855_RS06135 Protein ID WP_003881879.1
Coordinates 1313621..1314070 (+) Length 150 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID A0A100WWS2
Locus tag OF855_RS06130 Protein ID WP_054601330.1
Coordinates 1313438..1313617 (+) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF855_RS06115 (OF855_06120) 1308977..1309711 + 735 WP_003881875.1 enoyl-CoA hydratase -
OF855_RS06120 (OF855_06125) 1309713..1310819 + 1107 WP_269976420.1 MBL fold metallo-hydrolase -
OF855_RS06125 (OF855_06130) 1310886..1313378 + 2493 WP_269976421.1 cation-translocating P-type ATPase -
OF855_RS06130 (OF855_06135) 1313438..1313617 + 180 WP_054601330.1 antitoxin Antitoxin
OF855_RS06135 (OF855_06140) 1313621..1314070 + 450 WP_003881879.1 SRPBCC family protein Toxin
OF855_RS06140 (OF855_06145) 1314074..1314502 - 429 WP_061265375.1 hypothetical protein -
OF855_RS06145 (OF855_06150) 1314522..1315223 - 702 WP_003881881.1 hypothetical protein -
OF855_RS06150 (OF855_06155) 1315220..1315351 - 132 WP_003881882.1 hypothetical protein -
OF855_RS06155 (OF855_06160) 1315367..1316167 - 801 WP_065069857.1 CbbQ/NirQ/NorQ/GpvN family protein -
OF855_RS06160 (OF855_06165) 1316164..1317693 - 1530 WP_269976760.1 MorD protein -
OF855_RS06165 (OF855_06170) 1317845..1318447 - 603 WP_061265372.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-145)

Antitoxin

Antitoxin Rv0909/MT0933

(4-52)


Sequences

Toxin        


Download         Length: 150 a.a.        Molecular weight: 16117.67 Da        Isoelectric Point: 9.6573

>T261813 WP_003881879.1 NZ_CP107719:1313621-1314070 [Mycolicibacterium fortuitum]
MAKLSVSVEVPLPPEKAWEYASDLSRYDEWLSIHRAWRSKLPETLEKGTVIDSIVEVKGMLNRVKWTLVNYKPPQSLTLN
GDGRGGVKVKLIGKITPAAVDGGDGAKVSFDVHLGGPALFGPIGMVVAAALKGDIQQSLNKFKELYASS

Download         Length: 450 bp

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6406.10 Da        Isoelectric Point: 4.5045

>AT261813 WP_054601330.1 NZ_CP107719:1313438-1313617 [Mycolicibacterium fortuitum]
MGFLDKAKDLLSQNADKVEQAIEKAGDIVDEKTQGKYSGAVDKAQEAAKNAINKEEPQQ

Download         Length: 180 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A100WWS2

References