Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1279206..1279984 Replicon chromosome
Accession NZ_CP107717
Organism Xanthomonas campestris pv. campestris strain XY1-1

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8P667
Locus tag OF401_RS05360 Protein ID WP_011038220.1
Coordinates 1279206..1279697 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID Q8P668
Locus tag OF401_RS05365 Protein ID WP_011038219.1
Coordinates 1279694..1279984 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF401_RS05345 (OF401_05345) 1275534..1276409 + 876 WP_016945000.1 30S ribosomal protein S6--L-glutamate ligase -
OF401_RS05350 (OF401_05350) 1277059..1277736 + 678 WP_003490678.1 response regulator transcription factor -
OF401_RS05355 (OF401_05355) 1277729..1279063 + 1335 WP_057671653.1 HAMP domain-containing sensor histidine kinase -
OF401_RS05360 (OF401_05360) 1279206..1279697 - 492 WP_011038220.1 GNAT family N-acetyltransferase Toxin
OF401_RS05365 (OF401_05365) 1279694..1279984 - 291 WP_011038219.1 DUF1778 domain-containing protein Antitoxin
OF401_RS05370 (OF401_05370) 1280059..1280460 - 402 WP_040940795.1 SymE family type I addiction module toxin -
OF401_RS05375 (OF401_05375) 1280992..1281615 - 624 WP_011038217.1 dephospho-CoA kinase -
OF401_RS05380 (OF401_05380) 1281629..1282492 - 864 WP_057671659.1 A24 family peptidase -
OF401_RS05385 (OF401_05385) 1282499..1283761 - 1263 WP_057671824.1 type II secretion system F family protein -
OF401_RS05390 (OF401_05390) 1284103..1284531 + 429 WP_057671660.1 pilin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1237246..1293152 55906


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17638.31 Da        Isoelectric Point: 8.1192

>T261811 WP_011038220.1 NZ_CP107717:c1279697-1279206 [Xanthomonas campestris pv. campestris]
MTVSAPEPLTAHHRVEPFASGVESLDHWLKRRALKNQATGASRTFVACEDDRVVAYYALASSAVAVDATPGRFRRNMPDP
IPVVVLGRLAVDQSLHGRGFGRALMQDAGKRILHAADTIGIRGLLVHALSADAKAFYERIGFEPSPLDPMVLVVTLEDLK
ASL

Download         Length: 492 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.23 Da        Isoelectric Point: 10.5480

>AT261811 WP_011038219.1 NZ_CP107717:c1279984-1279694 [Xanthomonas campestris pv. campestris]
MSTPNTTPGKRETLNLRIKPEERSLIDRAAKARGKNRTDFMLDAARSAAEEALLDQTLITASPDAYAAFLARLDMPPQPN
ARLRKTMQTPAPWEKA

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8P667

Antitoxin

Source ID Structure
AlphaFold DB Q8P668

References