Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1914639..1916275 Replicon chromosome
Accession NZ_CP107616
Organism Acinetobacter baumannii strain 1326932

Toxin (Protein)


Gene name hipA Uniprot ID A0A335SV71
Locus tag OIO62_RS09055 Protein ID WP_000737060.1
Coordinates 1914639..1915970 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OIO62_RS09060 Protein ID WP_001101310.1
Coordinates 1915967..1916275 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OIO62_RS09035 (OIO62_09035) 1910950..1912113 + 1164 WP_001044488.1 hypothetical protein -
OIO62_RS09040 (OIO62_09040) 1912240..1913211 + 972 WP_094081187.1 5'/3'-nucleotidase SurE -
OIO62_RS09045 (OIO62_09045) 1913223..1913867 + 645 WP_000817320.1 hypothetical protein -
OIO62_RS09050 (OIO62_09050) 1913903..1914343 - 441 WP_000193138.1 HD domain-containing protein -
OIO62_RS09055 (OIO62_09055) 1914639..1915970 + 1332 WP_000737060.1 HipA domain-containing protein Toxin
OIO62_RS09060 (OIO62_09060) 1915967..1916275 + 309 WP_001101310.1 helix-turn-helix domain-containing protein Antitoxin
OIO62_RS09065 (OIO62_09065) 1917000..1917560 + 561 WP_025464545.1 TetR/AcrR family transcriptional regulator -
OIO62_RS09070 (OIO62_09070) 1917642..1918163 + 522 WP_001071843.1 hypothetical protein -
OIO62_RS09075 (OIO62_09075) 1918241..1919194 - 954 WP_264237791.1 ATP-dependent RecD-like DNA helicase -
OIO62_RS09080 (OIO62_09080) 1919272..1920240 + 969 WP_005804963.1 IS30 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1919230..1920240 1010


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-359)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 51188.22 Da        Isoelectric Point: 4.8490

>T261809 WP_000737060.1 NZ_CP107616:1914639-1915970 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELNYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEQFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFVCEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Download         Length: 1332 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11630.54 Da        Isoelectric Point: 9.9701

>AT261809 WP_001101310.1 NZ_CP107616:1915967-1916275 [Acinetobacter baumannii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A335SV71

Antitoxin

Source ID Structure

References