261794

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 14032..14620 Replicon plasmid unnamed1
Accession NZ_CP107604
Organism Acinetobacter baumannii strain 1326595

Toxin (Protein)


Gene name brnT Uniprot ID A0A0J8TIH5
Locus tag OIO71_RS19205 Protein ID WP_000438827.1
Coordinates 14032..14319 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag OIO71_RS19210 Protein ID WP_001983304.1
Coordinates 14306..14620 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OIO71_RS19175 (OIO71_19180) 9177..9512 + 336 WP_000064659.1 DUF6388 family protein -
OIO71_RS19180 (OIO71_19185) 9625..9771 - 147 WP_001983317.1 hypothetical protein -
OIO71_RS19185 (OIO71_19190) 10357..10632 + 276 WP_001133626.1 metal/formaldehyde-sensitive transcriptional repressor -
OIO71_RS19190 (OIO71_19195) 10654..11763 + 1110 WP_000842148.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
OIO71_RS19195 (OIO71_19200) 11816..12214 + 399 WP_000235176.1 VOC family protein -
OIO71_RS19200 (OIO71_19205) 12688..13521 + 834 WP_000439570.1 S-formylglutathione hydrolase -
OIO71_RS19205 (OIO71_19210) 14032..14319 + 288 WP_000438827.1 BrnT family toxin Toxin
OIO71_RS19210 (OIO71_19215) 14306..14620 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
OIO71_RS19215 (OIO71_19220) 14748..17159 + 2412 WP_000932942.1 TonB-dependent receptor ZnuD2 -
OIO71_RS19220 (OIO71_19225) 17464..17925 + 462 WP_000761346.1 DIP1984 family protein -
OIO71_RS19225 (OIO71_19230) 18251..18460 - 210 WP_000069474.1 hypothetical protein -
OIO71_RS19230 (OIO71_19235) 18453..18755 - 303 WP_001140621.1 XRE family transcriptional regulator -
OIO71_RS19235 (OIO71_19240) 18748..19104 - 357 WP_000269909.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..19662 19662


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11329.75 Da        Isoelectric Point: 5.6762

>T261794 WP_000438827.1 NZ_CP107604:14032-14319 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRYTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT261794 WP_001983304.1 NZ_CP107604:14306-14620 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J8TIH5

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References