Detailed information of TA system TA026179

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1932387..1932979
• Replicon: chromosome
• Accession: NC_017038
• Organism: Synechocystis sp. PCC 6803 substr. GT-I

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SYNGTI_RS09130
• Protein ID: WP_010872957.1
• Coordinates: 1932387..1932773 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: SYNGTI_RS09135
• Protein ID: WP_010872958.1
• Coordinates: 1932773..1932979 (-)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SYNGTI_RS09120	1930058..1931230	+	1173	WP_010872955.1	sulfate adenylyltransferase	-
SYNGTI_RS09125	1931273..1932337	+	1065	WP_010872956.1	glycosyltransferase	-
SYNGTI_RS09130	1932387..1932773	-	387	WP_010872957.1	type II toxin-antitoxin system VapC family toxin	Toxin
SYNGTI_RS09135	1932773..1932979	-	207	WP_010872958.1	DUF2281 domain-containing protein	Antitoxin
SYNGTI_RS09140	1933226..1934449	-	1224	WP_010872959.1	geranylgeranyl reductase	-
SYNGTI_RS09145	1934831..1935988	+	1158	WP_010872960.1	oxidoreductase	-
SYNGTI_RS09150	1936005..1936316	+	312	WP_010872961.1	DUF433 domain-containing protein	-
SYNGTI_RS09155	1936393..1937229	+	837	WP_010872962.1	DUF1049 domain-containing protein	-
SYNGTI_RS09160	1937348..1937701	+	354	WP_010872963.1	TMEM165/GDT1 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• VapC-like Sll0205 protein, PIN domain (5-127)

Antitoxin

• Domain of unknown function DUF2281 (7-67)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14814.14 Da
• Isoelectric Point: 6.0713

>T26179 WP_010872957.1 NC_017038:c1932773-1932387 [Synechocystis sp. PCC 6803 substr. GT-I]
MNSVLIDTHVFIWLAEDDSNLPVTTKDTLENMDNVFVSIASFWEISIKLKIGKLSLCGDFNSIEASFQRTRFKLLPITLK
DTIKLYNLPLHHKDPFDRILVSQSINHSLILVSRDQALDDYPIQRLWL

Nucleotide

• Length: 387 bp

>T26179 NC_017038:c1932773-1932387 [Synechocystis sp. PCC 6803 substr. GT-I]
ATGAATTCTGTTTTGATAGACACCCACGTTTTTATTTGGTTAGCAGAAGATGACTCTAACTTGCCTGTGACGACAAAAGA
TACCTTAGAAAATATGGATAACGTTTTTGTTAGTATTGCCAGCTTTTGGGAAATTTCTATTAAACTAAAAATTGGTAAAC
TTTCTCTCTGTGGTGATTTCAATAGTATTGAAGCTAGTTTTCAAAGAACCCGATTCAAGCTATTACCTATTACACTAAAA
GACACAATTAAACTTTATAATCTTCCCTTGCACCACAAAGATCCCTTTGATCGTATTTTGGTATCCCAATCGATTAATCA
TTCTCTTATTTTAGTCAGTCGTGATCAAGCTCTGGATGATTATCCGATTCAACGCCTGTGGTTGTAG

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7699.84 Da
• Isoelectric Point: 3.8804

>AT26179 WP_010872958.1 NC_017038:c1932979-1932773 [Synechocystis sp. PCC 6803 substr. GT-I]
MTTEAALLNIAENLPDDLKIELLHYAEYLMNKSLNAPQKPLAGSMKGTFILPLPEDFDAPLEEFEEYM

Nucleotide

• Length: 207 bp

>AT26179 NC_017038:c1932979-1932773 [Synechocystis sp. PCC 6803 substr. GT-I]
ATGACTACTGAAGCTGCCCTATTAAACATTGCTGAAAATCTGCCTGATGACTTAAAAATCGAGCTTTTACACTATGCTGA
ATATTTAATGAATAAATCCTTAAATGCGCCCCAAAAGCCATTAGCAGGATCGATGAAAGGAACTTTTATTTTACCTCTAC
CCGAAGACTTTGATGCCCCCTTAGAAGAATTTGAGGAGTATATGTAA