Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1914414..1916050 Replicon chromosome
Accession NZ_CP107599
Organism Acinetobacter baumannii strain 1326584

Toxin (Protein)


Gene name hipA Uniprot ID A0A335SV71
Locus tag OIO43_RS09045 Protein ID WP_000737060.1
Coordinates 1914414..1915745 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OIO43_RS09050 Protein ID WP_001101310.1
Coordinates 1915742..1916050 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OIO43_RS09025 (OIO43_09025) 1910725..1911888 + 1164 WP_001044488.1 hypothetical protein -
OIO43_RS09030 (OIO43_09030) 1912015..1912986 + 972 WP_094081187.1 5'/3'-nucleotidase SurE -
OIO43_RS09035 (OIO43_09035) 1912998..1913642 + 645 WP_000817320.1 hypothetical protein -
OIO43_RS09040 (OIO43_09040) 1913678..1914118 - 441 WP_000193138.1 HD domain-containing protein -
OIO43_RS09045 (OIO43_09045) 1914414..1915745 + 1332 WP_000737060.1 HipA domain-containing protein Toxin
OIO43_RS09050 (OIO43_09050) 1915742..1916050 + 309 WP_001101310.1 helix-turn-helix domain-containing protein Antitoxin
OIO43_RS09055 (OIO43_09055) 1916775..1917335 + 561 WP_025464545.1 TetR/AcrR family transcriptional regulator -
OIO43_RS09060 (OIO43_09060) 1917417..1917938 + 522 WP_001071843.1 hypothetical protein -
OIO43_RS09065 (OIO43_09065) 1918016..1918969 - 954 WP_264237791.1 ATP-dependent RecD-like DNA helicase -
OIO43_RS09070 (OIO43_09070) 1919047..1920015 + 969 WP_005804963.1 IS30 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1919005..1920015 1010


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-359)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 51188.22 Da        Isoelectric Point: 4.8490

>T261788 WP_000737060.1 NZ_CP107599:1914414-1915745 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELNYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEQFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFVCEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Download         Length: 1332 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11630.54 Da        Isoelectric Point: 9.9701

>AT261788 WP_001101310.1 NZ_CP107599:1915742-1916050 [Acinetobacter baumannii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A335SV71

Antitoxin

Source ID Structure

References