Detailed information of TA system TA261780

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1912687..1914323
• Replicon: chromosome
• Accession: NZ_CP107593
• Organism: Acinetobacter baumannii strain 1326580

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A335SV71
• Locus tag: OIO74_RS09065
• Protein ID: WP_000737060.1
• Coordinates: 1912687..1914018 (+)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: OIO74_RS09070
• Protein ID: WP_001101310.1
• Coordinates: 1914015..1914323 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OIO74_RS09045 (OIO74_09045)	1908998..1910161	+	1164	WP_001044488.1	hypothetical protein	-
OIO74_RS09050 (OIO74_09050)	1910288..1911259	+	972	WP_094081187.1	5'/3'-nucleotidase SurE	-
OIO74_RS09055 (OIO74_09055)	1911271..1911915	+	645	WP_000817320.1	hypothetical protein	-
OIO74_RS09060 (OIO74_09060)	1911951..1912391	-	441	WP_000193138.1	HD domain-containing protein	-
OIO74_RS09065 (OIO74_09065)	1912687..1914018	+	1332	WP_000737060.1	HipA domain-containing protein	Toxin
OIO74_RS09070 (OIO74_09070)	1914015..1914323	+	309	WP_001101310.1	helix-turn-helix domain-containing protein	Antitoxin
OIO74_RS09075 (OIO74_09075)	1915048..1915608	+	561	WP_025464545.1	TetR/AcrR family transcriptional regulator	-
OIO74_RS09080 (OIO74_09080)	1915690..1916211	+	522	WP_001071843.1	hypothetical protein	-
OIO74_RS09085 (OIO74_09085)	1916289..1917242	-	954	WP_264237791.1	ATP-dependent RecD-like DNA helicase	-
OIO74_RS09090 (OIO74_09090)	1917320..1918288	+	969	WP_005804963.1	IS30 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1917278..1918288	1010

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-359)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51188.22 Da
• Isoelectric Point: 4.8490

>T261780 WP_000737060.1 NZ_CP107593:1912687-1914018 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELNYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEQFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFVCEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T261780 NZ_CP107593:1912687-1914018 [Acinetobacter baumannii]
ATGAAAAAATTAACGATACAAGCTTTACTAAATAAAAACTGGATAGATATAGCAGAGCTAAAACTGCTGGAACCTAAGTT
GGGTTCGGCTAGCGCCAGTGAACTAGAGTATGAGTTGAATTATGCAATTCAATATTTAGACAGACGAGATGAGCACGCCT
GTAGTTTATCACTTCCTGTACAAATTCTTATCAAACACGAATCGGACACATGGTTTGGCTTTTTAGATGATATTGTTCCA
TCTGGCGCTGCACGCCGTTATTGGGTGAATTATCTAGATTTACAACGCTTAACCTATGCGGAACAAGAAAGTATTCTATT
AGAAAAAGGTGGGATGGCACCTGTTGGTAATTTACGAATTAAAGAAGCATTGCCTCCACTAAACCCAGAGTCAACCTTGC
ACTTACGTTATTTTAGTAAGGAAGATGTAGCTGAGCGTAATATTGATTTTCTGGAATATGCTCAACAAATGGGAGCAATT
AGTGGTGGTGCAACTGGTGCAGGCGGTGAAGCTCCCAAGTTGCTTATTCGTGTTTCACCAGAACAAAAAGTCTGGATTGA
CACCTACCAAGAACAATTTGATCAGCCAGATCAGCATTATTTAGTTAAATTTCCGCGAAATAAACGTAGCGAGATTGATT
GCGATATTCTCAGAGCTGAATATTATTACTATCAAATACTCAATGAGTTAGGTTTCAATACGATAGAGACGACTCAAATG
CAGCTTATTGAAGGTACAAAATATCCGTCATTGTGGCTTCCAAGATTCGATACAGAATGGTGTGATCAATATTGGCACCG
CTATGGTCTAGAGTCTGTGTATTCTGTACTAAATAAGTCTTCTGGTAGTCATCTTAATCATTTCGAAGTCATTGAAGATC
TATGTAGATTACTCACAAGCATTGACTCAGATTTTGATGTACCACAATTTGTTTGTGAGTGGTTACAACGAGATTTACTC
AATATCATTTTTGGTAATTCAGATAACCATGGGCGTAATACATCGTTTATAAAAAAATCTGGAAAAATTTATCTTTCGCC
TATTTATGACTTTGCACCTATGAAAGCCGATCCGGAAGTTGTGACCAGATCGACGACTTGGGGAAGTCCGTACGAGGAAG
GTGGTGAATACCGGTGGGCGCAAATTACACAAAAACTTGCTCCTTGGTGCGATCCCGATTTATCTCTAGCAACATTAAGG
ACTTTGGCGAATAACCTGCTTGGCTTAAAGCAACGATTAGTTGATAAAGGTGTACCCAAACAAATTATTGAAATGCCAGC
ACTGTCATTTGATTACATAGAAGCTAAATTGAAAAGATGGGAACTGCTATGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11630.54 Da
• Isoelectric Point: 9.9701

>AT261780 WP_001101310.1 NZ_CP107593:1914015-1914323 [Acinetobacter baumannii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Nucleotide

• Length: 309 bp

>AT261780 NZ_CP107593:1914015-1914323 [Acinetobacter baumannii]
ATGAATGTAAAAAATCAAACCCAAGACCGTCAGCAGATTCTTATAGATTTATATAAACAATATTTGTTGAGTGAGATTAC
TTTGGGGCAATTGCTATCGTATTTACGCAAAAATGTGTTGGGTTTGTCGCAAGAACAATATGCTAATTTGGTGGGTATAA
GCCGTCGGACTTTAACGGACATTGAGCAGGATAAAGGTAAACTCACTCAGTCTGTGTTAGATAAAGTGTTTAAACCACTT
GGTTTAAAAGCAGGGCTTGTACCTACGCATGAACATATTGTTAGCAAAATTATAAAGCCAAACGAGTAA

Structures

Toxin

• AlphaFold DB: A0A335SV71