261778

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 5655..6243 Replicon plasmid unnamed2
Accession NZ_CP107592
Organism Acinetobacter baumannii strain 1326569

Toxin (Protein)


Gene name brnT Uniprot ID A0A0J8TIH5
Locus tag OIO44_RS20120 Protein ID WP_000438827.1
Coordinates 5655..5942 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag OIO44_RS20125 Protein ID WP_001983304.1
Coordinates 5929..6243 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OIO44_RS20090 (OIO44_20095) 944..1519 + 576 WP_001096613.1 plasmid replication DNA-binding protein -
OIO44_RS20095 (OIO44_20100) 1531..1674 + 144 WP_001125246.1 hypothetical protein -
OIO44_RS20100 (OIO44_20105) 1980..2255 + 276 WP_001133626.1 metal/formaldehyde-sensitive transcriptional repressor -
OIO44_RS20105 (OIO44_20110) 2277..3386 + 1110 WP_000842148.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
OIO44_RS20110 (OIO44_20115) 3439..3837 + 399 WP_000235176.1 VOC family protein -
OIO44_RS20115 (OIO44_20120) 4311..5144 + 834 WP_000439570.1 S-formylglutathione hydrolase -
OIO44_RS20120 (OIO44_20125) 5655..5942 + 288 WP_000438827.1 BrnT family toxin Toxin
OIO44_RS20125 (OIO44_20130) 5929..6243 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
OIO44_RS20130 (OIO44_20135) 6371..8782 + 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
OIO44_RS20135 (OIO44_20140) 9087..9548 + 462 WP_000761346.1 DIP1984 family protein -
OIO44_RS20140 (OIO44_20145) 9871..10044 - 174 WP_001282482.1 hypothetical protein -
OIO44_RS20145 (OIO44_20150) 10044..10415 - 372 WP_000504219.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..11625 11625


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11329.75 Da        Isoelectric Point: 5.6762

>T261778 WP_000438827.1 NZ_CP107592:5655-5942 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRYTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT261778 WP_001983304.1 NZ_CP107592:5929-6243 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J8TIH5

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References