261769

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 273..861 Replicon plasmid unnamed1
Accession NZ_CP107586
Organism Acinetobacter baumannii strain 1326527-1

Toxin (Protein)


Gene name brnT Uniprot ID A0A0J8TIH5
Locus tag OIO72_RS19105 Protein ID WP_000438827.1
Coordinates 273..560 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag OIO72_RS19110 Protein ID WP_001983304.1
Coordinates 547..861 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OIO72_RS19105 (OIO72_19110) 273..560 + 288 WP_000438827.1 BrnT family toxin Toxin
OIO72_RS19110 (OIO72_19115) 547..861 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
OIO72_RS19115 (OIO72_19120) 989..3400 + 2412 WP_000932942.1 TonB-dependent receptor ZnuD2 -
OIO72_RS19120 (OIO72_19125) 3705..4166 + 462 WP_000761346.1 DIP1984 family protein -
OIO72_RS19125 (OIO72_19130) 4492..4701 - 210 WP_000069474.1 hypothetical protein -
OIO72_RS19130 (OIO72_19135) 4694..4996 - 303 WP_001140621.1 XRE family transcriptional regulator -
OIO72_RS19135 (OIO72_19140) 4989..5345 - 357 WP_000269909.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..19667 19667


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11329.75 Da        Isoelectric Point: 5.6762

>T261769 WP_000438827.1 NZ_CP107586:273-560 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRYTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT261769 WP_001983304.1 NZ_CP107586:547-861 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J8TIH5

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References