261767

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 14035..14623 Replicon plasmid unnamed1
Accession NZ_CP107584
Organism Acinetobacter baumannii strain 1326525-3

Toxin (Protein)


Gene name brnT Uniprot ID A0A0J8TIH5
Locus tag OIO75_RS19145 Protein ID WP_000438827.1
Coordinates 14035..14322 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag OIO75_RS19150 Protein ID WP_001983304.1
Coordinates 14309..14623 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OIO75_RS19120 (OIO75_19125) 11893..12105 + 213 WP_000687427.1 hypothetical protein -
OIO75_RS19125 (OIO75_19130) 12387..12563 + 177 WP_000246872.1 hypothetical protein -
OIO75_RS19130 (OIO75_19135) 12599..13093 + 495 WP_000999995.1 hypothetical protein -
OIO75_RS19135 (OIO75_19140) 13108..13392 - 285 WP_001071102.1 hypothetical protein -
OIO75_RS19140 (OIO75_19145) 13486..13788 + 303 WP_000702763.1 hypothetical protein -
OIO75_RS19145 (OIO75_19150) 14035..14322 + 288 WP_000438827.1 BrnT family toxin Toxin
OIO75_RS19150 (OIO75_19155) 14309..14623 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
OIO75_RS19155 (OIO75_19160) 14751..17162 + 2412 WP_000932942.1 TonB-dependent receptor ZnuD2 -
OIO75_RS19160 (OIO75_19165) 17467..17926 + 460 Protein_20 DIP1984 family protein -
OIO75_RS19165 (OIO75_19170) 18252..18461 - 210 WP_000069474.1 hypothetical protein -
OIO75_RS19170 (OIO75_19175) 18454..18756 - 303 WP_001140621.1 XRE family transcriptional regulator -
OIO75_RS19175 (OIO75_19180) 18749..19105 - 357 WP_000269909.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..19663 19663


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11329.75 Da        Isoelectric Point: 5.6762

>T261767 WP_000438827.1 NZ_CP107584:14035-14322 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRYTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT261767 WP_001983304.1 NZ_CP107584:14309-14623 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J8TIH5

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References