261760

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 14036..14624 Replicon plasmid unnamed1
Accession NZ_CP107578
Organism Acinetobacter baumannii strain 1326359

Toxin (Protein)


Gene name brnT Uniprot ID A0A0J8TIH5
Locus tag OIO45_RS19090 Protein ID WP_000438827.1
Coordinates 14036..14323 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag OIO45_RS19095 Protein ID WP_001983304.1
Coordinates 14310..14624 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OIO45_RS19065 (OIO45_19070) 11894..12106 + 213 WP_000687427.1 hypothetical protein -
OIO45_RS19070 (OIO45_19075) 12388..12564 + 177 WP_000246872.1 hypothetical protein -
OIO45_RS19075 (OIO45_19080) 12600..13094 + 495 WP_000999995.1 hypothetical protein -
OIO45_RS19080 (OIO45_19085) 13109..13393 - 285 WP_001071102.1 hypothetical protein -
OIO45_RS19085 (OIO45_19090) 13487..13789 + 303 WP_000702763.1 hypothetical protein -
OIO45_RS19090 (OIO45_19095) 14036..14323 + 288 WP_000438827.1 BrnT family toxin Toxin
OIO45_RS19095 (OIO45_19100) 14310..14624 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
OIO45_RS19100 (OIO45_19105) 14752..17163 + 2412 WP_000932942.1 TonB-dependent receptor ZnuD2 -
OIO45_RS19105 (OIO45_19110) 17468..17929 + 462 WP_000761346.1 DIP1984 family protein -
OIO45_RS19110 (OIO45_19115) 18255..18464 - 210 WP_000069474.1 hypothetical protein -
OIO45_RS19115 (OIO45_19120) 18457..18759 - 303 WP_001140621.1 XRE family transcriptional regulator -
OIO45_RS19120 (OIO45_19125) 18752..19108 - 357 WP_000269909.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..19667 19667


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11329.75 Da        Isoelectric Point: 5.6762

>T261760 WP_000438827.1 NZ_CP107578:14036-14323 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRYTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT261760 WP_001983304.1 NZ_CP107578:14310-14624 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J8TIH5

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References