Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4167789..4169356 Replicon chromosome
Accession NZ_CP107573
Organism Pantoea dispersa strain JL.02bL

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OF384_RS19520 Protein ID WP_150361077.1
Coordinates 4167789..4169099 (-) Length 437 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OF384_RS19525 Protein ID WP_104189496.1
Coordinates 4169099..4169356 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF384_RS19495 (OF384_19495) 4163285..4163947 - 663 WP_021506922.1 6-phosphogluconate phosphatase -
OF384_RS19500 (OF384_19500) 4164099..4165412 + 1314 WP_058770726.1 NCS2 family permease -
OF384_RS19505 (OF384_19505) 4165440..4166204 - 765 WP_031279602.1 4'-phosphopantetheinyl transferase -
OF384_RS19510 (OF384_19510) 4166498..4167007 + 510 WP_031279601.1 flavin reductase family protein -
OF384_RS19515 (OF384_19515) 4167049..4167639 - 591 WP_021506918.1 malonic semialdehyde reductase -
OF384_RS19520 (OF384_19520) 4167789..4169099 - 1311 WP_150361077.1 type II toxin-antitoxin system HipA family toxin Toxin
OF384_RS19525 (OF384_19525) 4169099..4169356 - 258 WP_104189496.1 helix-turn-helix domain-containing protein Antitoxin
OF384_RS19530 (OF384_19530) 4169564..4170928 - 1365 WP_088516155.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
OF384_RS19535 (OF384_19535) 4171009..4172655 - 1647 WP_021506916.1 membrane protein insertase YidC -
OF384_RS19540 (OF384_19540) 4172658..4172915 - 258 WP_264250068.1 membrane protein insertion efficiency factor YidD -
OF384_RS19545 (OF384_19545) 4172879..4173238 - 360 WP_040679622.1 ribonuclease P protein component -
OF384_RS19550 (OF384_19550) 4173254..4173394 - 141 WP_000831330.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 48983.10 Da        Isoelectric Point: 8.6926

>T261751 WP_150361077.1 NZ_CP107573:c4169099-4167789 [Pantoea dispersa]
MTELDVYMNGYRTGVFSRAATGAHTFRYYESWLNQPGSRPISLSMPLRHQPYKGAEVYNFFDNLLPDNPEIRARILSRYQ
ASSTQPFDLLAKVGSDTIGALQLLPPDSKPHTVRTIDYRRLSDSELEKILSGYQSGAPLGMLEELTDFRISLAGAQEKTA
LLRINQQWCLPQGNTPTTHILKLPIGNIQSHSHRIDLSDSVENEWLCTLIAREFGLAVPPCFIVNTGKIKALAVERFDRR
YASDGQWIMRLPQEDFCQVLNVPAAGKYESHGGPGISAIMDYLLNSVNAEQDRYDFMKAQVLFWLLAATDGHAKNFSIFI
EAEGRFRLTPFYDILSVYPVIGGAGLHIRDAKLAMGLNGSKGRKAAIEHIFPRHFIETAKTTKFALTAMAHILDEFRART
PEVIQRVQEQIPAAFPLRVSQTILNGFKARAARLQQ

Download         Length: 1311 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9677.11 Da        Isoelectric Point: 8.5776

>AT261751 WP_104189496.1 NZ_CP107573:c4169356-4169099 [Pantoea dispersa]
MKITSAKQLSSYLKDRRLTEALSQAKVASKIGIRQDTVSSFELQPETTRLDTLFRILAALDLEMEIKPRGLPSAKQDPDG
WKEEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References