Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3683234..3683933 Replicon chromosome
Accession NZ_CP107573
Organism Pantoea dispersa strain JL.02bL

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag OF384_RS17325 Protein ID WP_072208527.1
Coordinates 3683757..3683933 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OF384_RS17320 Protein ID WP_058780883.1
Coordinates 3683234..3683638 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF384_RS17305 (OF384_17305) 3680403..3680642 + 240 WP_264249640.1 hypothetical protein -
OF384_RS17310 (OF384_17310) 3680737..3682176 - 1440 WP_264251751.1 PTS N-acetylmuramic acid transporter subunit IIBC -
OF384_RS17315 (OF384_17315) 3682176..3683087 - 912 WP_058780882.1 N-acetylmuramic acid 6-phosphate etherase -
OF384_RS17320 (OF384_17320) 3683234..3683638 - 405 WP_058780883.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OF384_RS17325 (OF384_17325) 3683757..3683933 - 177 WP_072208527.1 type II toxin-antitoxin system HicA family toxin Toxin
OF384_RS17330 (OF384_17330) 3684109..3685410 - 1302 WP_021507820.1 glutamate/aspartate:proton symporter GltP -
OF384_RS17335 (OF384_17335) 3685991..3687946 + 1956 WP_264249644.1 acetate--CoA ligase -
OF384_RS17340 (OF384_17340) 3688120..3688449 + 330 WP_021313201.1 DUF485 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-55)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6824.11 Da        Isoelectric Point: 10.6691

>T261749 WP_072208527.1 NZ_CP107573:c3683933-3683757 [Pantoea dispersa]
MSSRELIRMLLERGWILDRVKGSHHVFVRADKPYHISLPHPEKDLATGTLRKLLKMMD

Download         Length: 177 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14641.36 Da        Isoelectric Point: 4.9322

>AT261749 WP_058780883.1 NZ_CP107573:c3683638-3683234 [Pantoea dispersa]
MRFPVYLHKTENGSWSGFVPDVQGCFFAGNTVDEALSDAFGAIDAHVESLADAGKAIPKAASVETHINDEECQGGYWAFV
EIDLSRYEGKAVKLNITLPQNLLSKIDSHVEAHREYGSRSGFLAALARRELANI

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References