Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1636909..1637526 Replicon chromosome
Accession NZ_CP107573
Organism Pantoea dispersa strain JL.02bL

Toxin (Protein)


Gene name hicA Uniprot ID A0A8E1RWX8
Locus tag OF384_RS07465 Protein ID WP_058771102.1
Coordinates 1636909..1637097 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OF384_RS07470 Protein ID WP_058781997.1
Coordinates 1637116..1637526 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF384_RS07450 (OF384_07450) 1633799..1634584 - 786 WP_264251495.1 PhnD/SsuA/transferrin family substrate-binding protein -
OF384_RS07455 (OF384_07455) 1634481..1635548 - 1068 WP_264251497.1 fatty acid desaturase -
OF384_RS07460 (OF384_07460) 1635766..1636788 + 1023 WP_264251500.1 LLM class flavin-dependent oxidoreductase -
OF384_RS07465 (OF384_07465) 1636909..1637097 + 189 WP_058771102.1 type II toxin-antitoxin system HicA family toxin Toxin
OF384_RS07470 (OF384_07470) 1637116..1637526 + 411 WP_058781997.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OF384_RS07475 (OF384_07475) 1637790..1638617 - 828 WP_058771104.1 glycosyltransferase family 8 protein -
OF384_RS07480 (OF384_07480) 1638636..1640018 - 1383 WP_264251504.1 D-arabinono-1,4-lactone oxidase -
OF384_RS07485 (OF384_07485) 1640097..1640738 - 642 WP_021509768.1 TetR family transcriptional regulator -
OF384_RS07490 (OF384_07490) 1640951..1641778 + 828 WP_088518052.1 MetQ/NlpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7028.26 Da        Isoelectric Point: 11.1475

>T261745 WP_058771102.1 NZ_CP107573:1636909-1637097 [Pantoea dispersa]
MDSRSLMAEIRADGWELIRINGSHHHFVHPTKKGLVTIPHPKKDLPIKTVKSIRKQAGLTVH

Download         Length: 189 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14780.06 Da        Isoelectric Point: 4.6268

>AT261745 WP_058781997.1 NZ_CP107573:1637116-1637526 [Pantoea dispersa]
MFYPIAIEAGDETTAYGVTVPDLPGCFSAGDTLEEAVKNAKEAITGHLELMVELGQDIPAVSDLKSLMKSAEFAGYVWVL
VDVDVTRILGGSEKINVTLPKLLIDRIDRCVATHPEFKTRSGFLAQVALERIAKTR

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References