Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 86259..86899 Replicon plasmid unnamed1
Accession NZ_CP107559
Organism Methylocystis sp. MJC1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag OGR47_RS19290 Protein ID WP_165056051.1
Coordinates 86492..86899 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag OGR47_RS19285 Protein ID WP_165056049.1
Coordinates 86259..86495 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OGR47_RS19260 (OGR47_19260) 81387..81584 - 198 WP_165056042.1 type II toxin-antitoxin system VapC family toxin -
OGR47_RS19265 (OGR47_19265) 81789..81998 - 210 WP_256367655.1 type II toxin-antitoxin system VapB family antitoxin -
OGR47_RS19270 (OGR47_19270) 82032..83369 - 1338 WP_165056044.1 plasmid replication protein RepC -
OGR47_RS19275 (OGR47_19275) 83541..84557 - 1017 WP_165056045.1 plasmid partitioning protein RepB -
OGR47_RS19280 (OGR47_19280) 84554..85762 - 1209 WP_165056047.1 plasmid partitioning protein RepA -
OGR47_RS19285 (OGR47_19285) 86259..86495 + 237 WP_165056049.1 antitoxin Antitoxin
OGR47_RS19290 (OGR47_19290) 86492..86899 + 408 WP_165056051.1 type II toxin-antitoxin system VapC family toxin Toxin
OGR47_RS19295 (OGR47_19295) 87331..88500 - 1170 WP_165056053.1 glycosyltransferase family 4 protein -
OGR47_RS19300 (OGR47_19300) 88667..90787 - 2121 WP_165056054.1 polysaccharide biosynthesis tyrosine autokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..353861 353861


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(10-58)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14599.81 Da        Isoelectric Point: 5.7560

>T261742 WP_165056051.1 NZ_CP107559:86492-86899 [Methylocystis sp. MJC1]
MTRYLLDTNIISDLIRRPSGAVASHIARVGEKNVCTSIIVAAELRYGCAKNSSKRLLQAVESLLGELDVLSLEEPVDMEY
GRIRAQLEQKGSPIGGNDLLIAAHALAVDATIVTANVNEFARVEGLKVENWLAAK

Download         Length: 408 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9033.43 Da        Isoelectric Point: 5.1881

>AT261742 WP_165056049.1 NZ_CP107559:86259-86495 [Methylocystis sp. MJC1]
MSAVRHVKLFRNGRNQAVRIPVEFELPGDEAILRREGDRLVLEPTRKRGLLALLETMQPVEEDFPEIEDRPPPAEKIF

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References