Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3804870..3805642 Replicon chromosome
Accession NZ_CP107558
Organism Methylocystis sp. MJC1

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag OGR47_RS18285 Protein ID WP_165049254.1
Coordinates 3804870..3805364 (-) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag OGR47_RS18290 Protein ID WP_165049256.1
Coordinates 3805361..3805642 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OGR47_RS18255 (OGR47_18255) 3799884..3800438 + 555 WP_165049241.1 TIGR02301 family protein -
OGR47_RS18260 (OGR47_18260) 3800518..3800769 + 252 WP_165049243.1 hypothetical protein -
OGR47_RS18265 (OGR47_18265) 3800911..3802008 + 1098 WP_165049245.1 histidine phosphatase family protein -
OGR47_RS18270 (OGR47_18270) 3802050..3803366 + 1317 WP_165049247.1 Nramp family divalent metal transporter -
OGR47_RS18275 (OGR47_18275) 3803510..3803800 + 291 WP_165049249.1 hypothetical protein -
OGR47_RS18280 (OGR47_18280) 3803914..3804873 + 960 WP_165049252.1 J domain-containing protein -
OGR47_RS18285 (OGR47_18285) 3804870..3805364 - 495 WP_165049254.1 GNAT family N-acetyltransferase Toxin
OGR47_RS18290 (OGR47_18290) 3805361..3805642 - 282 WP_165049256.1 DUF1778 domain-containing protein Antitoxin
OGR47_RS18295 (OGR47_18295) 3805769..3807064 + 1296 WP_165049258.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
OGR47_RS18300 (OGR47_18300) 3807155..3807982 - 828 WP_165049792.1 uracil-DNA glycosylase -
OGR47_RS18305 (OGR47_18305) 3808107..3808325 - 219 WP_165049261.1 YbdD/YjiX family protein -
OGR47_RS18310 (OGR47_18310) 3808300..3810381 - 2082 WP_165049263.1 carbon starvation CstA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(43-144)

Antitoxin

Vibrio phage ICP1, Orf50

(13-87)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 17498.22 Da        Isoelectric Point: 5.9126

>T261740 WP_165049254.1 NZ_CP107558:c3805364-3804870 [Methylocystis sp. MJC1]
VTLAAPRPISDADDISGFDCGVLALDDWLRRRARANQASGASRTYVVCEGNRVVAYFALASGAVDLDEATGRLRRNMPDP
VPVAVLGRLAIDRAWQKKGLGRALVKDALLRVLLAAETIGIRGMLVHALSPEAAAFYEAVGFEPSPLEPMTLMATLADLR
AALD

Download         Length: 495 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10551.06 Da        Isoelectric Point: 10.8833

>AT261740 WP_165049256.1 NZ_CP107558:c3805642-3805361 [Methylocystis sp. MJC1]
MSSKAQPAKRETLNLRIKPDDRSLIDRAAKLVSKSRTDFVLDAARNAAEEALLDKRLFRADAAAYADFVARLDAPPNPNE
RLRRTMKTRAPWE

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References