Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3307910..3309501 Replicon chromosome
Accession NZ_CP107549
Organism Pseudomonas sp. Z8(2022)

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OEG79_RS15835 Protein ID WP_264145916.1
Coordinates 3308176..3309501 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID W6RJ44
Locus tag OEG79_RS15830 Protein ID WP_003459718.1
Coordinates 3307910..3308176 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEG79_RS15810 (OEG79_15810) 3303315..3304805 + 1491 WP_264145913.1 methylenetetrahydrofolate reductase C-terminal domain-containing protein -
OEG79_RS15815 (OEG79_15815) 3304849..3305847 - 999 WP_264145914.1 bile acid:sodium symporter family protein -
OEG79_RS15820 (OEG79_15820) 3305929..3306723 + 795 WP_264145915.1 helix-turn-helix transcriptional regulator -
OEG79_RS15825 (OEG79_15825) 3307058..3307861 - 804 WP_126571865.1 inositol monophosphatase family protein -
OEG79_RS15830 (OEG79_15830) 3307910..3308176 - 267 WP_003459718.1 helix-turn-helix transcriptional regulator Antitoxin
OEG79_RS15835 (OEG79_15835) 3308176..3309501 - 1326 WP_264145916.1 HipA domain-containing protein Toxin
OEG79_RS15840 (OEG79_15840) 3309884..3310024 + 141 Protein_3097 IS3 family transposase -
OEG79_RS15845 (OEG79_15845) 3310170..3312368 + 2199 WP_264145917.1 OsmC domain/YcaO domain-containing protein -
OEG79_RS15850 (OEG79_15850) 3312371..3312958 + 588 WP_264145918.1 nucleotidyltransferase family protein -
OEG79_RS15855 (OEG79_15855) 3313050..3313907 + 858 WP_264145919.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3297783..3309501 11718


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-383)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 49134.72 Da        Isoelectric Point: 4.7298

>T261730 WP_264145916.1 NZ_CP107549:c3309501-3308176 [Pseudomonas sp. Z8(2022)]
MHNLTLQVYTDGQWRDAMAICFEQPEEGLEGVCAYGYQQGYLVDSLEFVGNRLNVAVSAAYPLGWDSWRDKKAPAFLLDI
LPSGAARRFLLKRLGGERPEGLNLDLYLLGRCTPAPIGNLRIKESVEAIAGSPVLGFTRDEVISRDVRFLEYAYEQGAAI
GGATGAGGEAPKLLLTEDRQGALHPDAVLPDADAAQHWFVKFARNKASQTDQDILRSEYCFYRAVQQLGIDTVAAEGLAL
EEGNKPSLWMHRFDREVGPAGVSRTAVESMYSLCGVTEAGSYMLHTQVLEKLVELWRAVGQEQQVGDLIFEYMRRDLLNQ
ILGNSDNHGRNTAILRCEQGVRLAPIYDLAPMVMDEEGVTRTTKWPKHIELAGEVNWRAACDEVSEWVDADDLFQRLRLA
AQEFLALPDLLSAEGLPDSTMSHPRIALRNLRQRLNQWGLV

Download         Length: 1326 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9933.55 Da        Isoelectric Point: 10.9502

>AT261730 WP_003459718.1 NZ_CP107549:c3308176-3307910 [Pseudomonas sp. Z8(2022)]
MDILERNRILNELQQQLASGEITIGGAVRRLRKEVTGLQQARFAQMCKLSLRALRQLELDESNPTVQTLNSVFNPFGMQV
GIVPKTPR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W6RJ44

References