Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/Txe-RelB
Location 209856..210363 Replicon chromosome
Accession NC_017028
Organism Candidatus Rickettsia amblyommii str. GAT-30V

Toxin (Protein)


Gene name relB Uniprot ID H8K422
Locus tag MCE_RS01155 Protein ID WP_014391804.1
Coordinates 210100..210363 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID H8K421
Locus tag MCE_RS01150 Protein ID WP_014391803.1
Coordinates 209856..210107 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MCE_RS01125 205023..206090 - 1068 WP_014391798.1 alanine racemase -
MCE_RS01130 206087..207106 - 1020 WP_014391799.1 ribose-phosphate diphosphokinase -
MCE_RS01135 207331..207930 - 600 WP_014391800.1 phospholipid-binding protein MlaC -
MCE_RS01140 207951..208706 - 756 WP_041860557.1 VacJ family lipoprotein -
MCE_RS01145 208711..209715 - 1005 WP_014391802.1 methyltransferase domain-containing protein -
MCE_RS01150 209856..210107 + 252 WP_014391803.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MCE_RS01155 210100..210363 + 264 WP_014391804.1 Txe/YoeB family addiction module toxin Toxin
MCE_RS01160 210423..211628 + 1206 WP_014391805.1 pyridoxal phosphate-dependent aminotransferase -
MCE_RS01165 211779..212435 + 657 WP_014391806.1 lysophospholipid acyltransferase family protein -
MCE_RS01170 212432..213826 + 1395 WP_014391807.1 lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase -
MCE_RS01175 213891..214319 - 429 WP_158309380.1 Sca4 family protein -
MCE_RS01180 214433..214837 - 405 Protein_235 hypothetical protein -
MCE_RS10010 215119..215238 - 120 WP_144010744.1 palindromic element RPE4 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10498.35 Da        Isoelectric Point: 9.6904

>T26173 WP_014391804.1 NC_017028:210100-210363 [Rickettsia amblyommatis str. GAT-30V]
MIEIEWTLEAAEDLACWKKYDIKKYERIKLLIKNIQEAPFIGIGKPEALKHILSGLWSRRINHEHRLIYSVNTKQIIIYN
CRFHYKN

Download         Length: 264 bp

>T26173 NC_017028:210100-210363 [Rickettsia amblyommatis str. GAT-30V]
ATGATTGAGATTGAGTGGACACTAGAAGCAGCGGAGGATTTAGCGTGTTGGAAAAAATATGATATTAAAAAATATGAACG
TATTAAACTTCTAATAAAAAATATCCAAGAAGCACCGTTTATAGGTATAGGTAAACCCGAAGCTTTAAAACATATATTAT
CAGGTTTATGGTCACGTAGAATTAACCACGAACATAGACTAATATATTCTGTCAATACTAAACAAATTATAATATATAAT
TGTAGATTTCATTATAAAAATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9521.77 Da        Isoelectric Point: 9.4884

>AT26173 WP_014391803.1 NC_017028:209856-210107 [Rickettsia amblyommatis str. GAT-30V]
MNSISGTSFRKNLSSVLNTVENDHVPYLIKRKNHKNIILLTEEEYESTKETLYLLSNPANANRIKKSIEQAKRGEFAKVN
LDD

Download         Length: 252 bp

>AT26173 NC_017028:209856-210107 [Rickettsia amblyommatis str. GAT-30V]
ATGAACTCAATTAGCGGCACTTCATTTAGAAAAAACTTAAGCTCTGTACTAAATACCGTAGAAAACGATCATGTCCCTTA
TCTTATTAAAAGAAAGAATCATAAGAATATTATTCTTTTAACAGAAGAAGAATATGAATCTACAAAAGAAACATTATATT
TATTATCTAATCCGGCTAATGCGAATCGAATAAAAAAATCTATCGAACAAGCAAAAAGAGGAGAGTTTGCTAAAGTTAAT
TTAGATGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H8K422

Antitoxin

Source ID Structure
AlphaFold DB A0A0C2M0P5

References