Detailed information of TA system TA261729

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Acetyltransf_4(toxin)
• Location: 1190568..1192000
• Replicon: chromosome
• Accession: NZ_CP107549
• Organism: Pseudomonas sp. Z8(2022)

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: OEG79_RS05650
• Protein ID: WP_264147820.1
• Coordinates: 1190568..1191137 (+)
• Length: 190 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: OEG79_RS05655
• Protein ID: WP_264147821.1
• Coordinates: 1191143..1192000 (+)
• Length: 286 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OEG79_RS05645 (OEG79_05650)	1186865..1190353	-	3489	WP_264147819.1	PAS domain-containing hybrid sensor histidine kinase/response regulator	-
OEG79_RS05650 (OEG79_05655)	1190568..1191137	+	570	WP_264147820.1	GNAT family protein	Toxin
OEG79_RS05655 (OEG79_05660)	1191143..1192000	+	858	WP_264147821.1	AraC family transcriptional regulator	Antitoxin
OEG79_RS05660 (OEG79_05665)	1192063..1193400	-	1338	WP_013716745.1	imelysin family protein	-
OEG79_RS05665 (OEG79_05670)	1193590..1194162	+	573	WP_264147822.1	LemA family protein	-
OEG79_RS05670 (OEG79_05675)	1194173..1195078	+	906	WP_264147823.1	E3 ubiquitin ligase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	sodB	1058549..1257899	199350

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (14-146)

Antitoxin

• AraC-type arabinose-binding/dimerisation domain (17-145)

Sequences

Toxin

Protein

• Length: 190 a.a.
• Molecular weight: 21580.79 Da
• Isoelectric Point: 8.0709

>T261729 WP_264147820.1 NZ_CP107549:1190568-1191137 [Pseudomonas sp. Z8(2022)]
MFKPQLVTLQRGALRLEPLSDADIPALVALAESNREELLYMSGTQRLDWYRSALTDLREQRALPFVIRLGDELVGTTRFA
DFMHTLPACEIGWTWIDRNQHGSGLNTTIKYLMLKHAFDNWGMVRVQLKTAASNLRSQRAIEKLGAVREGRLRNHRRLAD
GRLDDTVLYSITDLEWPALREAMEAGFVA

Nucleotide

• Length: 570 bp

Antitoxin

Protein

• Length: 286 a.a.
• Molecular weight: 31751.16 Da
• Isoelectric Point: 9.0437

>AT261729 WP_264147821.1 NZ_CP107549:1191143-1192000 [Pseudomonas sp. Z8(2022)]
MQAREQTRFWQASALSGVELLQARYLEQRFAPHVHEGFVFTVIEHGAQRFHHRGSDHLAPQGSMVLINPDEVHTGSKAHE
DGWRYRGFYPGNDQVLGALQELGLAKTGMPSFSFSVLHDPQLHSAFLQLHRLLDGGAEALQQQLAWREAILLLFQRHARL
AEPAAPGREPWAVACAKQMLADRLIEPPSLEELAAAVNLSPFHFARVFRRATGLPPHAWLKQRRLEQARALLKTGCTAVT
VATQLGFADQSHLSRQFKQVYGVSPGEYRSAVARIVAEGAPLGER

Nucleotide

• Length: 858 bp