Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 891354..891940 Replicon chromosome
Accession NZ_CP107532
Organism Methylobacterium sp. FF17

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag OF380_RS04010 Protein ID WP_264049500.1
Coordinates 891680..891940 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OF380_RS04005 Protein ID WP_264049499.1
Coordinates 891354..891683 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF380_RS03990 886702..887205 + 504 WP_264049495.1 N-acetyltransferase -
OF380_RS03995 887243..888175 + 933 WP_264049497.1 alpha/beta hydrolase -
OF380_RS04000 889244..891328 - 2085 WP_264049498.1 hypothetical protein -
OF380_RS04005 891354..891683 - 330 WP_264049499.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OF380_RS04010 891680..891940 - 261 WP_264049500.1 type II toxin-antitoxin system HicA family toxin Toxin
OF380_RS04015 892014..894833 - 2820 WP_264049501.1 DUF4159 domain-containing protein -
OF380_RS04020 894844..895779 - 936 WP_264049502.1 DUF58 domain-containing protein -
OF380_RS04025 895783..896787 - 1005 WP_264049503.1 MoxR family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-75)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9473.87 Da        Isoelectric Point: 11.0836

>T261719 WP_264049500.1 NZ_CP107532:c891940-891680 [Methylobacterium sp. FF17]
MKLSGRHRSTLEAIFAEPVRAGIAWSDIEAMLTAFGAEISEGRGSRVRIALNGVRAVFHRPHPQKETDKGAVKSMRRFLT
EAEATP

Download         Length: 261 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12254.83 Da        Isoelectric Point: 4.7423

>AT261719 WP_264049499.1 NZ_CP107532:c891683-891354 [Methylobacterium sp. FF17]
MTTMHCKGYEAVVEYDADADLFHGEVIDMRDVVTFQGRSVDELKQAFSDSIDDYLAFCAERGEEPEKPYSGQFVVRVEPV
LHRAVVSAAKRAGISLNKWVARTLERATI

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References