Detailed information of TA system TA261717

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 1472384..1473816
• Replicon: chromosome
• Accession: NZ_CP107524
• Organism: Streptococcus agalactiae strain SA5087

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: Q8DZ35
• Locus tag: OFY20_RS07610
• Protein ID: WP_001030302.1
• Coordinates: 1472971..1473816 (+)
• Length: 282 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: Q8DZ36
• Locus tag: OFY20_RS07605
• Protein ID: WP_000037239.1
• Coordinates: 1472384..1472974 (+)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OFY20_RS07605 (OFY20_07605)	1472384..1472974	+	591	WP_000037239.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
OFY20_RS07610 (OFY20_07610)	1472971..1473816	+	846	WP_001030302.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
OFY20_RS07615 (OFY20_07615)	1473902..1476703	-	2802	WP_000656698.1	phage tail tip lysozyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1452166..1487070	34904

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-257)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-50)

Sequences

Toxin

Protein

• Length: 282 a.a.
• Molecular weight: 32414.90 Da
• Isoelectric Point: 5.2111

>T261717 WP_001030302.1 NZ_CP107524:1472971-1473816 [Streptococcus agalactiae]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSSYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSEE
TVKQQLKEILADSEEGISFVIQSITTIKESDDYGGYRATISCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEDNFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKKDIDFNQLKNACQRTFSYRETELDFEKIIELLERFKSDP
TQNQQWQNYSKKYSYTKGISLANVLDEMISLITIIISTDSD

Nucleotide

• Length: 846 bp

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23074.63 Da
• Isoelectric Point: 7.8056

>AT261717 WP_000037239.1 NZ_CP107524:1472384-1472974 [Streptococcus agalactiae]
MSKKEILLDFIEKNNGIVTNKDCKALGIPTIYLTRLEKEGIIFRVEKGIFLTQNGDYDEYYFFQYRFPKAIFSYISALYL
QQFTDEIPQYFDVTVPRGYRFNTPPANLNIHFVSKEYSELGMTTVPTPMGNNVRVYDFERIICDFVIHREKIDSELFVKT
LQSYGNYPKKNLAKLYEYATKMNTLEKVKQTLEVLI

Nucleotide

• Length: 591 bp

Structures

Toxin

• AlphaFold DB: A8D822

Antitoxin

• AlphaFold DB: A0A2I7ZET8