261716

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) zeta-pezA/zeta-couple_hipB
Location 1361414..1362651 Replicon chromosome
Accession NZ_CP107524
Organism Streptococcus agalactiae strain SA5087

Toxin (Protein)


Gene name zeta Uniprot ID A0A068TM14
Locus tag OFY20_RS07045 Protein ID WP_074196747.1
Coordinates 1361414..1362175 (-) Length 254 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag OFY20_RS07050 Protein ID WP_000579610.1
Coordinates 1362175..1362651 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OFY20_RS07030 (OFY20_07030) 1357254..1357619 - 366 WP_000431642.1 MobC family plasmid mobilization relaxosome protein -
OFY20_RS07035 (OFY20_07035) 1357626..1357988 - 363 WP_000527641.1 SAG1252 family conjugative relaxosome accessory protein -
OFY20_RS07040 (OFY20_07040) 1358888..1361386 - 2499 WP_129299926.1 AAA family ATPase -
OFY20_RS07045 (OFY20_07045) 1361414..1362175 - 762 WP_074196747.1 type II toxin-antitoxin system toxin PezT Toxin
OFY20_RS07050 (OFY20_07050) 1362175..1362651 - 477 WP_000579610.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
OFY20_RS07055 (OFY20_07055) 1362719..1362991 - 273 WP_037612719.1 hypothetical protein -
OFY20_RS07060 (OFY20_07060) 1363029..1363412 - 384 WP_074196749.1 DUF5945 family protein -
OFY20_RS07065 (OFY20_07065) 1363409..1363642 - 234 WP_000152419.1 DUF5965 family protein -
OFY20_RS07070 (OFY20_07070) 1363693..1364778 - 1086 WP_074196750.1 toprim domain-containing protein -
OFY20_RS07075 (OFY20_07075) 1364788..1365429 - 642 WP_074196751.1 peptidylprolyl isomerase -
OFY20_RS07080 (OFY20_07080) 1365589..1365786 + 198 WP_001842085.1 hypothetical protein -
OFY20_RS07085 (OFY20_07085) 1365800..1366096 - 297 WP_074196752.1 DUF5966 family protein -
OFY20_RS07090 (OFY20_07090) 1366110..1366394 - 285 WP_074196753.1 DUF5962 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(26-214)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 254 a.a.        Molecular weight: 29073.02 Da        Isoelectric Point: 7.2767

>T261716 WP_074196747.1 NZ_CP107524:c1362175-1361414 [Streptococcus agalactiae]
MEIQDYTDSEFKHALARNLRSLTRGRKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTELSHLGYNLLIEGTLRTIDVPKKTAQLLKSRGYEVQLTLIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYKRDRSCVYDSGEDTTSAATVLHDLLFGEWNQVEKEML
KVGEKRLNELHEK

Download         Length: 762 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18217.63 Da        Isoelectric Point: 4.3457

>AT261716 WP_000579610.1 NZ_CP107524:c1362651-1362175 [Streptococcus agalactiae]
MIGKNIKSLRKTHDLTQPEFAQIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A068TM14

Antitoxin

Source ID Structure

References