Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 1170607..1171164 Replicon chromosome
Accession NZ_CP107524
Organism Streptococcus agalactiae strain SA5087

Toxin (Protein)


Gene name relE Uniprot ID G5KI09
Locus tag OFY20_RS06190 Protein ID WP_003047235.1
Coordinates 1170892..1171164 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G5KI08
Locus tag OFY20_RS06185 Protein ID WP_001140275.1
Coordinates 1170607..1170888 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OFY20_RS06155 (OFY20_06155) 1165971..1166420 - 450 WP_050152615.1 DUF4314 domain-containing protein -
OFY20_RS06160 (OFY20_06160) 1166422..1166673 - 252 WP_017646680.1 hypothetical protein -
OFY20_RS06165 (OFY20_06165) 1166735..1168015 - 1281 WP_050152616.1 DNA (cytosine-5-)-methyltransferase -
OFY20_RS06170 (OFY20_06170) 1168012..1168602 - 591 WP_000073292.1 HNH endonuclease -
OFY20_RS06175 (OFY20_06175) 1168602..1169855 - 1254 WP_006740451.1 site-specific DNA-methyltransferase -
OFY20_RS06180 (OFY20_06180) 1169827..1170282 - 456 WP_000999415.1 hypothetical protein -
OFY20_RS06185 (OFY20_06185) 1170607..1170888 + 282 WP_001140275.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OFY20_RS06190 (OFY20_06190) 1170892..1171164 + 273 WP_003047235.1 type II toxin-antitoxin system YafQ family toxin Toxin
OFY20_RS06195 (OFY20_06195) 1171207..1171566 - 360 WP_001138026.1 HNH endonuclease -
OFY20_RS06200 (OFY20_06200) 1171568..1172308 - 741 WP_003047233.1 methionine adenosyltransferase domain-containing protein -
OFY20_RS06205 (OFY20_06205) 1172712..1173209 - 498 WP_006738435.1 hypothetical protein -
OFY20_RS06210 (OFY20_06210) 1173202..1174578 - 1377 WP_000773770.1 DEAD/DEAH box helicase -
OFY20_RS06215 (OFY20_06215) 1174559..1174840 - 282 WP_001208489.1 VRR-NUC domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1143125..1181792 38667


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-90)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10433.06 Da        Isoelectric Point: 8.9949

>T261715 WP_003047235.1 NZ_CP107524:1170892-1171164 [Streptococcus agalactiae]
MLQLVTTNQFRKDVKRAKKRGLNLKKLEAVLDPLQKEETLDEKHRDHALVGNYMGFRECHIEPDWLLVYAIDKGQLILTA
SRTGSHSDLF

Download         Length: 273 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10323.68 Da        Isoelectric Point: 4.4155

>AT261715 WP_001140275.1 NZ_CP107524:1170607-1170888 [Streptococcus agalactiae]
MAKTANINLRIEPSTKAQAESLFGSFGISVTDAINIFLNTSIMEGGFPFQIKQPRYNRETELAMEEARQIMEGKVTTKSY
ASVSDLMADLNED

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829ID91

References