Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 238157..238769 Replicon chromosome
Accession NZ_CP107524
Organism Streptococcus agalactiae strain SA5087

Toxin (Protein)


Gene name parE Uniprot ID Q8E7D3
Locus tag OFY20_RS01395 Protein ID WP_000384859.1
Coordinates 238157..238492 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q8E7D2
Locus tag OFY20_RS01400 Protein ID WP_000259017.1
Coordinates 238482..238769 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OFY20_RS01370 (OFY20_01370) 233355..233996 + 642 WP_000591145.1 hypothetical protein -
OFY20_RS01375 (OFY20_01375) 234296..235171 + 876 WP_000421240.1 hypothetical protein -
OFY20_RS01380 (OFY20_01380) 235207..235641 + 435 WP_001220482.1 hypothetical protein -
OFY20_RS01385 (OFY20_01385) 235958..237214 + 1257 WP_000122836.1 MobV family relaxase -
OFY20_RS01390 (OFY20_01390) 237382..237852 + 471 WP_000130119.1 hypothetical protein -
OFY20_RS01395 (OFY20_01395) 238157..238492 - 336 WP_000384859.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OFY20_RS01400 (OFY20_01400) 238482..238769 - 288 WP_000259017.1 hypothetical protein Antitoxin
OFY20_RS01405 (OFY20_01405) 239276..239566 + 291 WP_000078283.1 WXG100 family type VII secretion target -
OFY20_RS01410 (OFY20_01410) 239668..240075 + 408 WP_000749954.1 hypothetical protein -
OFY20_RS01415 (OFY20_01415) 240075..240635 + 561 WP_001865562.1 hypothetical protein -
OFY20_RS01420 (OFY20_01420) 240608..240871 + 264 Protein_224 hypothetical protein -
OFY20_RS01425 (OFY20_01425) 240908..241713 + 806 WP_088181596.1 IS5-like element IS1381A family transposase -
OFY20_RS01430 (OFY20_01430) 241730..242149 + 420 Protein_226 hypothetical protein -
OFY20_RS01435 (OFY20_01435) 242134..242520 + 387 WP_000259069.1 hypothetical protein -
OFY20_RS01440 (OFY20_01440) 242554..242835 + 282 WP_000052406.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 230187..239043 8856


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13296.98 Da        Isoelectric Point: 4.6565

>T261714 WP_000384859.1 NZ_CP107524:c238492-238157 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10906.50 Da        Isoelectric Point: 4.7271

>AT261714 WP_000259017.1 NZ_CP107524:c238769-238482 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A076Z4V6

References