Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 896930..897504 Replicon chromosome
Accession NC_017027
Organism Pasteurella multocida subsp. multocida str. HN06

Toxin (Protein)


Gene name PumA Uniprot ID A0A849CFF7
Locus tag PMCN06_RS04175 Protein ID WP_014667974.1
Coordinates 897220..897504 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A849CG04
Locus tag PMCN06_RS04170 Protein ID WP_014391174.1
Coordinates 896930..897223 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMCN06_RS04150 892096..893187 - 1092 WP_005756839.1 L-ascorbate 6-phosphate lactonase -
PMCN06_RS04155 893536..895326 + 1791 WP_014391171.1 PTS ascorbate-specific subunit IIBC -
PMCN06_RS04160 895371..895838 + 468 WP_014391172.1 PTS sugar transporter subunit IIA -
PMCN06_RS04165 895856..896533 + 678 WP_014391173.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
PMCN06_RS04170 896930..897223 - 294 WP_014391174.1 putative addiction module antidote protein Antitoxin
PMCN06_RS04175 897220..897504 - 285 WP_014667974.1 addiction module protein Toxin
PMCN06_RS04180 898798..899059 - 262 Protein_807 hypothetical protein -
PMCN06_RS04185 899231..899555 - 325 Protein_808 hypothetical protein -
PMCN06_RS04190 899855..902041 - 2187 WP_014391179.1 S8 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 898798..898959 161


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-85)

Antitoxin

Uncharacterized protein HI1420

(5-92)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10702.41 Da        Isoelectric Point: 10.2849

>T26171 WP_014667974.1 NC_017027:c897504-897220 [Pasteurella multocida subsp. multocida str. HN06]
VGRLREVKNLSAKAAVLARINRVMNGNLGDHKSIGNGLYEMRIIKGSGYRVYYGQYREVTYLLICGGDKSTQKSDIVKAR
ELWKEIKQQEEVKV

Download         Length: 285 bp

>T26171 NC_017027:c897504-897220 [Pasteurella multocida subsp. multocida str. HN06]
GTGGGTCGGTTAAGGGAGGTAAAAAATTTATCCGCCAAAGCCGCTGTTCTTGCTCGTATTAACAGAGTAATGAATGGTAA
TTTGGGCGATCATAAATCGATTGGAAATGGATTGTATGAGATGAGAATTATAAAAGGTTCGGGTTATAGAGTTTACTATG
GACAATATAGAGAAGTAACTTATTTATTAATTTGTGGTGGCGATAAATCAACACAGAAATCAGACATTGTTAAAGCGAGA
GAGTTGTGGAAAGAAATAAAGCAACAAGAGGAAGTAAAAGTATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.80 Da        Isoelectric Point: 8.9149

>AT26171 WP_014391174.1 NC_017027:c897223-896930 [Pasteurella multocida subsp. multocida str. HN06]
MSKKKIKLKLFDIAEHLDSEEMIAAYLSEVLETCDTNEFISALADVVRAKGMTELAAKTGLRRESLYKTLSYGSKPRFDT
IMKITHSLGIKLVPTHI

Download         Length: 294 bp

>AT26171 NC_017027:c897223-896930 [Pasteurella multocida subsp. multocida str. HN06]
ATGAGTAAGAAAAAAATAAAATTAAAACTGTTTGATATTGCTGAACATCTAGACAGTGAAGAAATGATTGCGGCATATTT
AAGTGAAGTTTTAGAAACATGTGATACTAATGAATTTATTTCCGCTTTAGCTGATGTTGTAAGAGCAAAAGGAATGACGG
AGTTAGCAGCAAAAACAGGGTTAAGAAGAGAAAGCCTCTATAAAACATTATCATACGGTAGCAAGCCACGTTTTGATACG
ATAATGAAAATTACGCATTCATTAGGTATTAAACTTGTCCCAACGCACATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A849CFF7

Antitoxin

Source ID Structure
AlphaFold DB A0A849CG04

References