261692

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2653830..2654455 Replicon chromosome
Accession NZ_CP107518
Organism Klebsiella pneumoniae strain CRKP_1

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag OH528_RS13050 Protein ID WP_002882817.1
Coordinates 2653830..2654213 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag OH528_RS13055 Protein ID WP_004150355.1
Coordinates 2654213..2654455 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH528_RS13035 2651196..2652098 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
OH528_RS13040 2652095..2652730 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
OH528_RS13045 2652727..2653656 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
OH528_RS13050 2653830..2654213 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
OH528_RS13055 2654213..2654455 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
OH528_RS13060 2654660..2655577 + 918 WP_002882812.1 alpha/beta hydrolase -
OH528_RS13065 2655591..2656532 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
OH528_RS13070 2656577..2657014 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
OH528_RS13075 2657011..2657871 - 861 WP_002882807.1 virulence factor BrkB family protein -
OH528_RS13080 2657865..2658464 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T261692 WP_002882817.1 NZ_CP107518:c2654213-2653830 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT261692 WP_004150355.1 NZ_CP107518:c2654455-2654213 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References