Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1148769..1149333 Replicon chromosome
Accession NC_016948
Organism Mycobacterium intracellulare MOTT-64

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag OCQ_RS05650 Protein ID WP_041784823.1
Coordinates 1148962..1149333 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag OCQ_RS05645 Protein ID WP_026071432.1
Coordinates 1148769..1148975 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCQ_RS05625 1144384..1145382 + 999 WP_008254378.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
OCQ_RS05630 1145428..1146573 - 1146 WP_179960060.1 hypothetical protein -
OCQ_RS05635 1146715..1147788 + 1074 WP_009953440.1 redox-regulated ATPase YchF -
OCQ_RS05640 1147868..1148530 - 663 WP_014384000.1 methyltransferase domain-containing protein -
OCQ_RS05645 1148769..1148975 + 207 WP_026071432.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
OCQ_RS05650 1148962..1149333 + 372 WP_041784823.1 type II toxin-antitoxin system VapC family toxin Toxin
OCQ_RS05655 1149391..1149942 + 552 WP_038535279.1 VOC family protein -
OCQ_RS05660 1150021..1150419 + 399 WP_009953435.1 VOC family protein -
OCQ_RS05665 1150566..1150901 + 336 WP_014379387.1 hypothetical protein -
OCQ_RS26865 1150987..1151346 + 360 WP_179960061.1 hypothetical protein -
OCQ_RS05675 1151528..1152103 + 576 WP_139826564.1 C40 family peptidase -
OCQ_RS05680 1152466..1152789 + 324 WP_009953431.1 antibiotic biosynthesis monooxygenase -
OCQ_RS05685 1152838..1153521 - 684 WP_014384004.1 hypothetical protein -
OCQ_RS25830 1153668..1153877 + 210 WP_014381976.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-112)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13877.21 Da        Isoelectric Point: 6.9118

>T26169 WP_041784823.1 NC_016948:1148962-1149333 [Mycobacterium paraintracellulare]
VILVDTSIWIDHLHVAEHRLVGRLTNDEIGCHQMVIEELALGMIKQRDDVLRLLSHLREFPLLTHAEILHLVDRRRLWGR
GLSAIDAHLLGSVAVVDGARLWTRDKKLKAACKEVGVAIVDES

Download         Length: 372 bp

>T26169 NC_016948:1148962-1149333 [Mycobacterium paraintracellulare]
GTGATCCTCGTTGACACATCGATATGGATTGACCATCTGCACGTCGCCGAGCATCGCCTCGTCGGCCGCTTGACCAACGA
CGAAATCGGTTGCCACCAAATGGTGATCGAGGAGCTGGCACTCGGTATGATCAAGCAGCGCGACGACGTACTGAGATTGC
TGTCCCATCTGCGCGAGTTTCCGTTGTTGACGCACGCGGAAATCCTCCATCTCGTTGACCGTCGCCGCTTGTGGGGAAGG
GGATTGAGCGCAATCGACGCCCACCTTCTTGGGTCGGTTGCTGTCGTCGACGGTGCACGGCTTTGGACGAGGGACAAGAA
GTTGAAAGCGGCGTGTAAAGAAGTGGGTGTTGCGATCGTCGATGAGTCGTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7250.31 Da        Isoelectric Point: 11.9169

>AT26169 WP_026071432.1 NC_016948:1148769-1148975 [Mycobacterium paraintracellulare]
MRTTVTIDDALLAQAAELTGVTESAALLRQGLQTLIRVESARRLAALGGTDPKASAAPRRRPPTRDPR

Download         Length: 207 bp

>AT26169 NC_016948:1148769-1148975 [Mycobacterium paraintracellulare]
ATGAGGACAACAGTGACCATCGACGATGCCTTACTGGCTCAGGCGGCGGAACTGACCGGCGTGACGGAGAGTGCGGCGCT
TCTCCGTCAGGGATTGCAGACCCTCATTCGGGTAGAGAGCGCCCGCCGTCTCGCGGCGCTCGGCGGCACGGACCCCAAGG
CGTCGGCCGCCCCGCGGCGGAGGCCGCCGACCCGTGATCCTCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References