Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 150269..151014 Replicon plasmid unnamed1
Accession NZ_CP107514
Organism Klebsiella pneumoniae strain CRKP_2

Toxin (Protein)


Gene name tacT Uniprot ID A0A331KSM6
Locus tag OH512_RS27745 Protein ID WP_032408901.1
Coordinates 150269..150760 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag OH512_RS27750 Protein ID WP_014386183.1
Coordinates 150748..151014 (-) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH512_RS27720 145953..146708 + 756 WP_032408898.1 DeoR/GlpR family DNA-binding transcription regulator -
OH512_RS27725 146970..147410 + 441 WP_014386179.1 transposase -
OH512_RS27730 147407..147757 + 351 WP_014386180.1 IS66 family insertion sequence element accessory protein TnpB -
OH512_RS27735 147788..149380 + 1593 Protein_163 IS66 family transposase -
OH512_RS27740 149577..149828 + 252 WP_032408900.1 aldo/keto reductase -
OH512_RS27745 150269..150760 - 492 WP_032408901.1 GNAT family N-acetyltransferase Toxin
OH512_RS27750 150748..151014 - 267 WP_014386183.1 DUF1778 domain-containing protein Antitoxin
OH512_RS27755 151250..151369 + 120 WP_223156217.1 type I toxin-antitoxin system Hok family toxin -
OH512_RS27760 151613..152098 - 486 WP_014386185.1 hypothetical protein -
OH512_RS27765 152288..152560 + 273 WP_032408902.1 hypothetical protein -
OH512_RS27770 152557..152907 + 351 WP_014386186.1 hypothetical protein -
OH512_RS27775 153544..153870 + 327 WP_014386187.1 hypothetical protein -
OH512_RS27780 153932..154144 + 213 WP_014386188.1 hypothetical protein -
OH512_RS27785 154155..154379 + 225 WP_014386189.1 hypothetical protein -
OH512_RS27790 154460..154780 + 321 WP_014386190.1 type II toxin-antitoxin system RelE/ParE family toxin -
OH512_RS27795 154770..155048 + 279 WP_004152721.1 helix-turn-helix transcriptional regulator -
OH512_RS27800 155049..155462 + 414 WP_013023817.1 helix-turn-helix domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mph(A) / sul1 / qacE / aadA2 / dfrA12 / aph(3')-Ia - 1..206705 206705


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(89-149)

Antitoxin

(2-87)


Sequences


Toxin        


Download         Length: 164 a.a.        Molecular weight: 17667.46 Da        Isoelectric Point: 8.8757

>T261677 WP_032408901.1 NZ_CP107514:c150760-150269 [Klebsiella pneumoniae]
VGKVTAPVPLGTSHILAEFHCGEPVLDEWIKHRGLKNQSLGAARTFVVCRGNASQVLAYYSLATGSVTHAIAPGSLRRNM
PDPVPVIILARLAVDTSYHGQGLGADLLHDAVLRCCRVAENIGVRAVMVHALSDSARQFYIHHGFIPSQTQDRTLFLRLP
LIT

Download         Length: 492 bp


Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.66 Da        Isoelectric Point: 5.1169

>AT261677 WP_014386183.1 NZ_CP107514:c151014-150748 [Klebsiella pneumoniae]
MKSDVQLNIRAKEAQRALIDTAAEILHKSRTDFILEMACQAAENVILDRRMFNLNDEQYAEFIDMLDAPVTANPAMEKLL
ARKPQWAK

Download         Length: 267 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A331KSM6


Antitoxin

Source ID Structure

References