Detailed information of TA system TA026167

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 2602368..2603360
• Replicon: chromosome
• Accession: NC_016947
• Organism: Mycobacterium intracellulare MOTT-02

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: OCO_RS12070
• Protein ID: WP_014382490.1
• Coordinates: 2602782..2603360 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: OCO_RS12065
• Protein ID: WP_014382489.1
• Coordinates: 2602368..2602757 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCO_RS12040	2597820..2599823	+	2004	WP_014382487.1	phosphotransferase	-
OCO_RS12045	2599820..2600365	+	546	WP_051012195.1	gluconokinase	-
OCO_RS12050	2600389..2601000	-	612	WP_009956383.1	TetR/AcrR family transcriptional regulator	-
OCO_RS12055	2601192..2601995	+	804	WP_009956382.1	SAM-dependent methyltransferase	-
OCO_RS12060	2602035..2602310	+	276	WP_014380061.1	hypothetical protein	-
OCO_RS12065	2602368..2602757	+	390	WP_014382489.1	hypothetical protein	Antitoxin
OCO_RS12070	2602782..2603360	+	579	WP_014382490.1	zeta toxin family protein	Toxin
OCO_RS12075	2603380..2604447	-	1068	WP_014380064.1	DoxX family membrane protein	-
OCO_RS12080	2604543..2605103	+	561	WP_026071602.1	pyrazinamidase PncA	-
OCO_RS12085	2605103..2605903	+	801	WP_014382492.1	nuclear transport factor 2 family protein	-
OCO_RS12090	2605915..2606265	-	351	WP_020188920.1	DoxX family protein	-
OCO_RS12095	2606431..2607402	+	972	WP_014382494.1	sigma-70 family RNA polymerase sigma factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-137)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21077.18 Da
• Isoelectric Point: 11.0233

>T26167 WP_014382490.1 NC_016947:2602782-2603360 [Mycobacterium intracellulare MOTT-02]
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPGESAGRAYDAAQIAAATRAKLIDLGRSFIAETVFSH
PSKLDLIRTAHRAGFTVVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDNSRLRG
PRIVARLSGGMTIGSPDWPAWAPEILRSRWPD

Nucleotide

• Length: 579 bp

>T26167 NC_016947:2602782-2603360 [Mycobacterium intracellulare MOTT-02]
ATGCAGCGACTTGACCTGGTGGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACCCTGGCGCCGCTGTT
GCCCGGCAGCCCGGTCGTCAACGCCGATGAGATCGCAAGGCAGCGCTGGCCGGGGGAGTCGGCGGGGCGCGCCTACGACG
CCGCGCAAATCGCCGCCGCCACGCGCGCGAAGTTGATCGACCTGGGGCGGTCGTTCATCGCGGAGACCGTGTTTTCCCAC
CCGTCGAAGCTGGACCTCATCCGCACCGCCCACCGAGCGGGCTTCACCGTCGTCCTGCACGCGATGCTCATCCCGGAAGA
CCTTGCCGTCGAACGTGTCCGGCACCGCGTGCGGGCCGGTGGCCACGACGTACCGGAAACCAAGGTTCGCGAGCGCCATC
GTCGCTTGTGGACACCGGTCACCGACGCCATCGCGCTTTCCGACGTCGCCACCGTCTACGACAACAGCCGGCTGCGCGGG
CCGCGCATTGTCGCCCGCCTCAGCGGCGGCATGACGATCGGTTCACCGGACTGGCCGGCGTGGGCTCCGGAGATCTTGCG
GTCGCGCTGGCCGGACTAG

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13498.86 Da
• Isoelectric Point: 5.1743

>AT26167 WP_014382489.1 NC_016947:2602368-2602757 [Mycobacterium intracellulare MOTT-02]
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGQLATGELTVEEGVVFNAEI
SAAIDESLVHADYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR

Nucleotide

• Length: 390 bp

>AT26167 NC_016947:2602368-2602757 [Mycobacterium intracellulare MOTT-02]
ATGGCCGACGCTCCCGATCGTGTGACCCGCGTGGCGTCCGACCTGATGGACAGCGCGGCCTCCGAAGGCGCCCGCCAGAG
CCGTTCGGCCAAGCAGCAACTCGACCACTGGGCGCGTGTCGGGCGCGCGGTGTCCAGCCAGCACACCGCCTCGCGGCGGC
GGGTCGAGGCCGCGCTGGCCGGCCAGCTGGCGACCGGCGAACTCACCGTCGAGGAAGGCGTGGTGTTCAACGCCGAGATC
TCCGCCGCCATCGACGAAAGCCTGGTGCACGCCGACTACGGGGCGACGCTGGCCGGGCATGGCGTCACCACGGTCGCCCT
CAACGAGGACGGCGACATCGTCGAGCACCGGCCCGATGGCGCCGCCGTGGTGCTGGCGCGCGGGCGCTGA