Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2649315..2649940 Replicon chromosome
Accession NZ_CP107513
Organism Klebsiella pneumoniae strain CRKP_2

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag OH512_RS13030 Protein ID WP_002882817.1
Coordinates 2649315..2649698 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag OH512_RS13035 Protein ID WP_004150355.1
Coordinates 2649698..2649940 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH512_RS13015 2646681..2647583 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
OH512_RS13020 2647580..2648215 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
OH512_RS13025 2648212..2649141 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
OH512_RS13030 2649315..2649698 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
OH512_RS13035 2649698..2649940 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
OH512_RS13040 2650145..2651062 + 918 WP_002882812.1 alpha/beta hydrolase -
OH512_RS13045 2651076..2652017 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
OH512_RS13050 2652062..2652499 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
OH512_RS13055 2652496..2653356 - 861 WP_002882807.1 virulence factor BrkB family protein -
OH512_RS13060 2653350..2653949 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T261667 WP_002882817.1 NZ_CP107513:c2649698-2649315 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT261667 WP_004150355.1 NZ_CP107513:c2649940-2649698 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References