Detailed information of TA system TA026166

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1137175..1137739
• Replicon: chromosome
• Accession: NC_016947
• Organism: Mycobacterium intracellulare MOTT-02

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: H8IVI4
• Locus tag: OCO_RS05595
• Protein ID: WP_009953437.1
• Coordinates: 1137368..1137739 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: OCO_RS05590
• Protein ID: WP_026071432.1
• Coordinates: 1137175..1137381 (+)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCO_RS05570	1132796..1133794	+	999	WP_008254378.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
OCO_RS05575	1133840..1134979	-	1140	WP_179293415.1	hypothetical protein	-
OCO_RS05580	1135121..1136194	+	1074	WP_009953440.1	redox-regulated ATPase YchF	-
OCO_RS05585	1136274..1136936	-	663	WP_014379386.1	methyltransferase domain-containing protein	-
OCO_RS05590	1137175..1137381	+	207	WP_026071432.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
OCO_RS05595	1137368..1137739	+	372	WP_009953437.1	type II toxin-antitoxin system VapC family toxin	Toxin
OCO_RS05600	1137797..1138348	+	552	WP_009953436.1	VOC family protein	-
OCO_RS05605	1138427..1138825	+	399	WP_009953435.1	VOC family protein	-
OCO_RS05610	1138924..1139307	+	384	WP_026071433.1	hypothetical protein	-
OCO_RS26320	1139393..1139752	+	360	WP_179293417.1	hypothetical protein	-
OCO_RS05620	1139934..1140509	+	576	WP_085977620.1	C40 family peptidase	-
OCO_RS05625	1140872..1141195	+	324	WP_009953431.1	antibiotic biosynthesis monooxygenase	-
OCO_RS05630	1141244..1141927	-	684	WP_014384004.1	hypothetical protein	-
OCO_RS25300	1142074..1142283	+	210	WP_014381976.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13868.20 Da
• Isoelectric Point: 6.8398

>T26166 WP_009953437.1 NC_016947:1137368-1137739 [Mycobacterium intracellulare MOTT-02]
VILVDTSIWIDHLHVAEQRLVGRLTNDEIGCHQMVIEELALGMIKQRDDVLRLLSHLREFPLLTHAEILHLVDRRRLWGR
GLSAIDAHLLGSVAVVDGARLWTRDKKLKAACKEVGVAIVDES

Nucleotide

• Length: 372 bp

>T26166 NC_016947:1137368-1137739 [Mycobacterium intracellulare MOTT-02]
GTGATCCTCGTTGACACATCGATATGGATTGACCATCTGCACGTCGCCGAGCAGCGCCTCGTCGGCCGCTTGACCAACGA
CGAAATCGGTTGCCACCAAATGGTGATCGAGGAGCTGGCACTCGGTATGATCAAGCAGCGCGACGACGTACTGAGATTGC
TGTCCCATCTGCGCGAGTTTCCGTTGTTGACGCACGCGGAAATCCTCCATCTCGTTGACCGTCGCCGCTTGTGGGGAAGG
GGATTGAGTGCAATCGACGCCCACCTTCTTGGGTCGGTTGCTGTCGTCGACGGTGCACGGCTTTGGACGAGGGACAAGAA
GTTGAAAGCGGCGTGTAAAGAAGTGGGTGTTGCGATCGTCGATGAGTCGTGA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7250.31 Da
• Isoelectric Point: 11.9169

>AT26166 WP_026071432.1 NC_016947:1137175-1137381 [Mycobacterium intracellulare MOTT-02]
MRTTVTIDDALLAQAAELTGVTESAALLRQGLQTLIRVESARRLAALGGTDPKASAAPRRRPPTRDPR

Nucleotide

• Length: 207 bp

>AT26166 NC_016947:1137175-1137381 [Mycobacterium intracellulare MOTT-02]
ATGAGGACAACAGTGACCATCGACGATGCCTTACTGGCTCAGGCGGCGGAACTGACCGGCGTGACGGAGAGTGCGGCGCT
TCTCCGTCAGGGATTGCAGACCCTCATTCGGGTAGAGAGCGCCCGCCGTCTCGCGGCGCTCGGCGGCACGGACCCCAAGG
CGTCGGCCGCCCCGCGGCGGAGGCCGCCGACCCGTGATCCTCGTTGA

Structures

Toxin

• AlphaFold DB: A0A7R7MQX9